By M.D. Esben Kirk
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Additional info for Acidosis. Clinical Aspects and Treatment with Isotonic Sodium Bicarbonate Solution
The early administration of alkalies in cholera has been effective in preventing death from cholera«. Sellards and Shaklee 1 9 8 in 1911, on the intravenous treatment with isotonic sodium bicarbonate solution. Despite the fact that it is almost 90 years since the cholera devastated Denmark as a regular epidemic, this disease still deserves special mention as the representative of a group of diseases in which acidosis occurs with special severity and frequency. The considerable similarity in the course of cholera, the severest forms of infantile diarrhea, and the more rarely occurring choleriform diarrheas in adults renders it probable that the observations and experience from the treatment of cholera may be referred with advantage to the cholera-like diseases occurring in our latitudes.
December 29, 1831. Dr. Robert Lewins117, to the Board of Health in London, in which the effect is described as »most wonderful and satisfactory«. From numerous articles in The Lancet in the months that follow it appears that the treatment attained a considerable popularity and undoubtedly in several cases resulted in the curing of otherwise hopeless cases of cholera, since apparently it was not rarely possible to resuscitate Cholera 51 already moribund patients. The treatment met with much opposition but also early gained support in influential quarters.
C. to 1,50 p. c. The case terminated with the recovery of the patient. After Sellards, A. W. and Shaklee, A. , Philippine J. c. in the course of 5 hours. Even after anuria of 24 hours' duration it was often possible to induce diuresis by a bicarbonate injection, while this could rarely be accomplished after the injection of Ringer's solution. In a single case, in which a total of 90 g of sodium bicarbonate was injected, diuresis was re-established after 3 days' anuria. The first portion of urine, which was passed 18 hours after the injection, was colourless like water; the subsequent portions contained increasing amounts of urine pigment, and the case terminated with the recovery of the patient.