By F. Spreafico, A. Mantovani, R. Giavazzi, G. Conti, A. Anaclerio (auth.), Prof. G. Mathé, Dr. G. Bonadonna, Prof. S. Salmon (eds.)
Transplantation of syngeneic (donor is a monozygous dual) or allogeneic (donor is an HLA-identical sibling) marrow offers the chance for competitive antileukemic treatment with out regard to marrow toxicity. till 1975, marrow transplantation used to be conducted simply after failure of all different remedy. for that reason, so much sufferers have been in complex relapse. Six of sixteen recipients of syngeneic marrow and thirteen of a hundred recipients of allogeneic marrow are nonetheless in remission after five. 5-10 years [3, 7]. An actuarial survival curve of the 1st a hundred sufferers grafted in Seattle after conditioning with cyclophos phamide (60 mg/kg on each one of two successive days) and overall physique irradiation (1,000 rad) confirmed 3 classes of curiosity: (1) the 1st four months confirmed a swift lack of sufferers linked to complicated disease, graft-versus-host ailment, infections (in specific interstitial pneumonias), and recurrent leukemia; (2) from four months to two years, the curve confirmed a far slower fee of decline attributable essentially to recurrent leukemia; and (3) from 2-10 years, the curve was once nearly flat with a negligible lack of sufferers and no recurrent leukemia. This flat section of the curve corresponded to thirteen% of the sufferers and shows a powerful chance that most of those survivors are cured in their illness . makes an attempt at lowering the prevalence of leukemic relapse after transplantation have been made via a few marrow transplant teams through extra chemotherapy.
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4. Actuarial curve of survival of the poor-prognosis ALL and leukemic lymphosarcoma patients of all ages 1200 Fig. 5. 20 , , 'n=9 ALU/15y. 50 days 200 400 600 800 1000 An Intensive Chemo- or Chemoimmunotherapy Regimen 35 It is too early to analyse the effect of Azimexon. We are only making a preliminary check of the feasability of protocol 16 and of its possible superiority over protocol 12, which had given us mediocre results on a population of ALL patients defined by one of our parameters. The present preliminary results indicate the applicability of this protocol 16 and its encouraging results in such ALL patients and LL patients.