By Susannah Yovino, Young Kwok (auth.), Philip Rubin, Louis S. Constine, Lawrence B. Marks (eds.)
The literature at the past due results of melanoma therapy is largely scattered in numerous journals on the grounds that all significant organ structures are affected and administration relies on various scientific and surgical remedies. the purpose of "ALERT – hostile past due results of melanoma therapy" is to supply a coherent multidisciplinary method of the care of melanoma survivors. quantity 2 of this two-volume paintings comprehensively records capability overdue results in all of the general tissue anatomic websites within the human physique. The detection, analysis, administration and prevention of results are all thought of intimately, and prognostic results are mentioned. Radiation danger elements and interactions with chemotherapy results are in actual fact awarded. The textual content is followed through various supportive illustrations and tables. it truly is expected that this textbook turns into the surest in supplying info at the past due results of melanoma remedy and that, in its digitized shape, it will likely be referenced in melanoma survivorship guidelines.
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Extra info for ALERT • Adverse Late Effects of Cancer Treatment: Volume 2: Normal Tissue Specific Sites and Systems
Int J Radat Oncol Biol Phys 6(9):1215–1228 Silber J, Radcliffe J, Peckham V et al (1992) Whole brain radiation and decline in intelligence: the influence of dose and age on IQ score. J Clin Oncol 10(9):1390–1396 Sloan A, Arnold S, St. Clair W et al (2003) Brain injury: current management and investigations. Sem Radiat Oncol 13(3):309–321 Smith RE Jr, Aapro MS, Ludwig H et al (2008) Darbepoetin alpha for the treatment of anemia in patients with active cancer not receiving chemotherapy or radiotherapy: results of a phase III, multicenter, randomized, double-blind, placebo-controlled study.
The benefit of hyperbaric oxygen (HBO) therapy for radiation-induced CNS toxicity has been investigated in a number of small trials (Hulshof et al. 2002; Ohguri et al. 2007; Chuba et al. 1997). No consistent benefit has been reported and no large randomized trial has been conducted. At this point, there is insufficient evidence to recommend for or against HBO in patients with CNS toxicity secondary to radiotherapy. Pentoxifylline, which may also improve tissue oxygenation and down-regulate inflammatory cytokines, has also been suggested as a treatment for radionecrosis and RT-induced cranial and peripheral nerve injury.
10. Note the steep increase in incidence of necrosis with dose. 2 Fig. 8 Resolving Radiation Necrosis: the above images illustrate a case of proven radiation necrosis. 5 cm metastatic solitary brain metastasis from non-small cell lung cancer. 5 Gy fractions of whole brain radiation, followed by radiosurgery boost to 24 Gy. Two years after radiosurgery boost, she developed radiation necrosis. Patient was almost asymptomatic; therefore, she was managed conservatively with no medical intervention.