By Professor Dr. Endre Kelemen, Professor Dr. Wenceslao Calvo, Professor Dr. Theodor M. Fliedner (auth.)
During the prior twenty years, celJ biology has made tremendous strides that have thoroughly remodeled the normal morphological hematology of the day prior to this. This development is basically a result of advent of latest thoughts which permit practical instead of anatomic reviews: labeling strategies have made attainable the learn of celJ kinetics from delivery to demise of a celJ: tradition strategies (both in vivo and in vitro) have made it attainable to set up the progeny of definite stern celJs, their development poten tiaL and the mechanisms in their law. the consequences were so outstanding and feature so aroused the keenness 01' younger hematologists that it has develop into trendy in so me quarters to think about the microscope an "extinct tool" and morphology littlc greater than an superseded (if agreeable) hobby of little clinical curiosity. one of many results is the want of a few investigators to review cytology with no the help of their eyes. the current booklet makes us discover once again that morphology is the technology of constitution and form and that its goal isn't really to colJect photographs yet to appreciate them. it really is actual that microscopic statement, even if made with the electron microscope, can't on its own resolution a few easy questions of celJ biology. even if, the hematologist who makes use of just a unmarried strategy is sort of a one who may describe the realm from the viewpoint of a unmarried sensory organ and may refuse assistance from the others.
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In the past twenty years, celJ biology has made huge strides that have thoroughly remodeled the widely used morphological hematology of the previous day. This development is essentially because of the advent of latest concepts which permit sensible instead of anatomic reviews: labeling ideas have made attainable the research of celJ kinetics from beginning to dying of a celJ: tradition innovations (both in vivo and in vitro) have made it attainable to set up the progeny of yes stern celJs, their progress poten tiaL and the mechanisms in their law.
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2% of a11 nucleated ce11s present in the cord blood of a 7-8-week-old embryo to 3% in the heart blood of a 21-week-old fetus. Band and segmented neutrophils were not found in the blood from the 4th to the 7th week. 2 % of a11 nucleated blood ce11s) in the heart blood at 9 to 10 weeks and were about 4% in the cord blood of an 11-12-week-old fetus. Their percentage continued to increase from 7% at the 14th week to 16% of a11 nucleated ce11s at the 21st week (heart blood). 5% of a11 nucleated ce11s) in the heart blood from the 16th week onward.
Their number increased rapidly and reached 73% in the cord blood of an 11-12-week-old fetus, 40% in the cord blood of a 14-week-old fetus, and around 57% and 37% in the heart blood of 16and 22-week-old fetuses, respectively. Definitive (nonnucleated) erythrocytes began to appear at the 7th week and increased rapidly during the next 2 weeks. Figure 4 shows the percent increase of erythrocytes during the period of time in which yolk sac-type hemopoiesis subsides. Megalocytes and occasional giant erythrocytes were seen from the 4th to the 10th week.
There is an abundance of glycogen (coarse black granules) throughout the cytoplasm of the endodermal cells. 7 A hemopoietic progenitor cell in an endodermal cell pocket of the endoderm of the yolk sac of a 7-week-old embryo (20-mm eR length). ittle endoplasmic reticulum, suggesting the beginning of formation of demarcation membranes. Its megakaryoblastic nature may weil be considered. 8 a Yolk sac of a 7-8-week-old embryo. Two proerythroblasts contained in the endodermal celllayer with numerous contact areas betwen the hemopoietic cells and the endoderm.