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Additional resources for Biochemistry: Concepts and Connections
But their chemical structures were poorly understood, and than physical or chemical prodifferent. in the early 1900s nucleic acids were thought to be simple substances, cesses. In other words, the ferfit only for structural roles in the cell. Most biochemists believed that mentation of sugar into ethanol could occur only in whole, living cells. only proteins were sufficiently complex to carry genetic information. The vitalist dogma was shattered in 1897 when two German That belief turned out to be incorrect.
Biochemistry as a Discipline and an Interdisciplinary Science In trying to define biochemistry, we must consider it both as an interdisciplinary field and as a distinct discipline. 3 The recent history of biochemistry as shown by the introduction of new research techniques. • Synthetic biology 2010 • In vivo NMR • Chromatin immunoprecipitation/ sequencing • Induced pluripotent cells • Second generation 2005 DNA sequence analysis • Proteomic analysis with mass spectrometry 2000 • Gene analysis on microchips • Single-molecule dynamics 1995 • Targeted gene disruption • Atomic force microscopy 1990 • Scanning tunneling microscopy The timeline begins with the introduction of radioisotopes as biochemical reagents, immediately following World War II.
These biopolymers are made by joining together prefabricated units, or monomers. Of the four classes of macromolecules, three of them are biopolymers: proteins, nucleic acids, and carbohydrates. Lipids, the fourth class of macromolecule, are not considered polymers and are discussed in the next section. The monomers of a given type of macromolecule are of limited diversity and are linked together, or polymerized, by identical mechanisms. Each process involves condensation, or removal of a molecule of water in the joining reaction.