Breast Cancer Stem Cells & Therapy Resistance by Phuc Van Pham

By Phuc Van Pham

This quantity completely examines breast melanoma stem cells (BCSCs), from simple definitions to thoughts for choosing, separating, culturing, and focusing on BCSCs for remedy; there's extra specialise in pre-clinical and medical effects. The textual content starts off with a dialogue of breast melanoma, focusing specifically at the obstacles of present remedies in its remedy. the following chapters introduce and examine stem cells and melanoma stem cells, describe homes and isolation recommendations of BCSCs, and consider BCSC-targeting ways. The textual content concludes with a dialogue of controversy surrounding the BCSC speculation and of destiny study instructions. Breast melanoma Stem Cells & treatment Resistance, a part of the SpringerBriefs in Stem Cells sequence, presents a succinct but complete assessment of BCSCs for complicated scholars, graduate scholars and researchers in addition to these operating with breast melanoma or stem cells in a scientific setting.

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Fehm, T. (2014). Expression of stem cell and epithelial-mesenchymal transition markers in circulating tumor cells of breast cancer patients. BioMed Research International, 2014, 415721. , & Laterra, J. (2012). Cancer stem cells: Distinct entities or dynamically regulated phenotypes? Cancer Research, 72(3), 576–580. , … Xu, B. (2013). Stem cell marker aldehyde dehydrogenase 1 (ALDH1)-expressing cells are enriched in triple-negative breast cancer. The International Journal of Biological Markers 28(4), e357–364.

This suggested that CSCs and their progenitor cancer cells co-exist in a dynamic form (Li & Laterra, 2012). The relationship between CSCs and cancer progenitor cells creates the necessity to specify a combination of markers for the identification of CSCs. Heterogeneity in the BCSC Population: Which Is the Strongest Sub-population? Several recent studies have shown that BCSCs contain sub-populations that exhibit different tumorigenicity. To date, only some of these subpopulations have been identified.

2005). Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples. Stem Cells, 23(6), 752–760. 2004-0292. , … Di Fiore, P. P. (2010). Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell, 140(1), 62–73. 007. Pham, P. , Phan, N. , Nguyen, N. , Truong, N. , Duong, T. , Le, D. , … Phan, N. K. (2011). Differentiation of breast cancer stem cells by knockdown of CD44: Promising differentiation therapy.

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