Cancer Chemo- and Immunopharmacology: 1. Chemopharmacology by F. M. Muggia, J. Henney, V. DeVita Jr. (auth.), Professor

By F. M. Muggia, J. Henney, V. DeVita Jr. (auth.), Professor Georges Mathé, Professor Franco M. Muggia (eds.)

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With phase III studies of new drugs the multitude of possibilities increases. Drugs found to be active in a phase II setting are often moved immediately into combination studies. These combination studies make single-drug efficacy vs single-drug toxicity difficult to successfully interpret. The designs become muddled because strategies begin to overlap. The strategy becomes dominated by how best to treat a given tumor, Clinical Chemotherapy: Its Correlation with Experimental Models 33 at a given clinical and pathologic stage, and this tends to overwhelm the strategy of new drug evaluation.

E. Second Nephroblastoma Trial. Proc Xth Meet Int Soc Pediatr Oncol, Bruxelles, pp 7-9 39 Panettiere FJ, Heilbrun L (1980) Effectiveness of postoperative adjuvant therapy with methyl CCNU plus 5-FU with or without oral BCG in an attempt to prevent recurrence of Dukes B2 or C colon cancer. Interim report of a continuing SWOG study. In: Salmon SE, Jones SE (eds) Adjuvant therapy cancer II. Grune and Stratton, New York, pp 595-602 40 Paoletti P, Butti G, Casotto A, Grunta F, Knerich R, Marini G, Mazza C, Robustelli della Cuna G, Schiffer D, Soffietti R (1979) Italian multicenter study on malignant brain tumor Adjuvant Therapies of Postsurgical Minimal Residual Disease 41 42 43 44 45 46 47 48 49 50 51 52 53 25 therapy.

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