Cell Signaling & Molecular Targets in Cancer by Alessio Giubellino (auth.), Malay Chatterjee, Khosrow Kashfi

By Alessio Giubellino (auth.), Malay Chatterjee, Khosrow Kashfi (eds.)

This publication presents an summary of serious elements of phone signaling equipment and its position in epithelial morphogenesis, proliferation, invasions and angiogenesis in human melanoma and discusses novel different types of protein kinase pathways.

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They discovered that the depletion of arginine was the underlying mechanism. Gill and Pan in 1970 found that addition of arginine could reverse the inhibition of cell division in L5178Y cells by arginine-degrading Mycoplasma and the possible role of arginine L. edu M. Chatterjee and K. 1007/978-1-4614-0730-0_3, © Springer Science+Business Media, LLC 2012 37 38 N. Savaraj et al. deiminase [3]. Subsequently, Fenske and Kenny reported on the role of arginine deiminase in the growth of Mycoplasma [4], and Weickmann and Fahrney provided evidence of multiple forms of arginine deiminase from Mycoplasma [5].

It will be important to define targets that are most likely to be uniquely involved in these processes. To address the problem of low efficacy for some single agent therapies, and to target a complex process such as metastasis, combinations of drugs acting at different signaling nodes will probably be needed. Drugs targeting protein–protein interactions hold the promise of fewer side effects and when used in combinations, may realize a better therapeutic efficacy than conventional medications. Disease-relevant intracellular protein–protein interactions are promising drug targets, especially where cancer cells are dependent on the activity of a specific oncogene.

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