Checkpoint Responses in Cancer Therapy by Erik S. Knudsen, Wesley A. Braden (auth.), Wei Dai PhD

By Erik S. Knudsen, Wesley A. Braden (auth.), Wei Dai PhD (eds.)

Extensive study has exposed a suite of molecular surveillance mechanisms – usually known as "checkpoints" – which tightly visual display unit cell-cycle strategies. Today’s anticancer drug improvement has pointed out a lot of those cell-cycle checkpoint molecules as powerful ambitions. learn now provides to discover a brand new iteration of anticancer medications with better healing indices in line with their skill to focus on rising checkpoint elements. Checkpoint Responses in melanoma remedy summarizes the advances remodeled the earlier two decades, making a choice on parts of cell-cycle checkpoints and their molecular law in the course of checkpoint activation and validating using checkpoint proteins as goals for the advance of anticancer medications. This book’s unique panel of authors takes a detailed examine themes starting from the most important molecular gamers affecting DNA synthesis and the reaction to DNA harm to advances made within the id of chemicals in a position to inhibiting person mitotic kinases. Illuminating and authoritative, Checkpoint Responses in melanoma remedy deals a serious precis of findings for researchers within the pharmaceutical and biotechnology industries and a invaluable source for educational scientists in melanoma examine and the research of cell-cycle legislation, sign transduction and apoptosis.

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2,000 cpds in a cellular proliferation assay screen for novel p53 reactivators (87) (Fig. 2A). Compounds have been tested for their ability to inhibit the growth of Saos-2 tumor cell lines transfected with the p53 mutant His-273. PRIMA-1 has been found to restore p53-dependent apoptosis in several tumor cell lines with different p53 status and to restore wild-type p53 conformation and DNAbinding activity in cell extracts as well as in living cells. In contrast to CP31398, PRIMA-1 appears to be able to rescue wild-type p53 26 Klein and Vassilev conformation of both DNA contact and structural p53 mutants and inhibits tumor growth in xenograft models (87).

Work conducted by independent laboratories have supported part of these findings and have reported a selective induction of apoptosis by PRIMA-1 in mutant p53 cells via the c-JunNH2-kinase pathway (91). Recently, a new family of p53 reactivators derived from the backbone of PRIMA-1 were described (92). Myers et al. (2005) have found that PRIMA-1 and their derivatives selectively eliminate mutant p53 cells, however, they have been unable to find any evidence for restoration of wild-type p53 properties including p53-induced reporter gene activation in vitro (92).

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