Chemical Biology of Nucleic Acids: Fundamentals and Clinical by Volker A. Erdmann, Wojciech T. Markiewicz, Jan Barciszewski

By Volker A. Erdmann, Wojciech T. Markiewicz, Jan Barciszewski

This quantity comprises 29 engrossing chapters contributed by means of around the world, prime examine teams within the box of chemical biology. themes contain pre-biology; the institution of the genetic code; isomerization of RNA; harm of nucleobases in RNA; the dynamic constitution of nucleic acids and their analogs in DNA replication, additional- and intra-cellular delivery; molecular crowding by means of ionic beverages; new applied sciences permitting the amendment of gene expression through enhancing of healing genes; using riboswitches; the amendment of mRNA cap areas; new techniques to observe adequately changed RNAs with EPR spectroscopy and using parallel and high-throughput thoughts for the research of the constitution and new capabilities of nucleic acids. This quantity discusses how chemistry can upload new frontiers to the sector of nucleic acids in molecular drugs, biotechnology and nanotechnology and isn't simply a useful resource of knowledge to chemists, biochemists and existence scientists yet also will stimulate destiny research.

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Extra resources for Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications

Sample text

7 From the Early Decoding System to the Universal Decoding System . . . . . . . . . . . 8 Concluding Remarks and Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 27 28 31 32 33 35 36 38 Abstract Mitochondria are intracellular organelles in eukaryotic cells that have their own genome and translational apparatus.

The 30 -terminus of RNA is catalytically highly competent; it carries out conformationally defined internal movements by spontaneously switching between (pseudo) equatorial–axial and axial–equatorial at low energetic costs—pyranosyls are too rigid for this. As for lyxose, either one of its secondary hydroxyls is sterically too hindered in α- or β-lyxofuranosyl nucleotides. ” Which emphasises again the importance of finding chemical systems that will kick-start translation off its yet unknown grounds.

6 Metal Ion-Promoted Isomerization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Effect of Thio Substitution and Alkylation of a Non-bridging Oxygen on Isomerization 8 Epilogue . .

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