Chemotherapy: Volume 7 Cancer Chemotherapy I by Emil Frei III (auth.), K. Hellmann, T. A. Connors (eds.)

By Emil Frei III (auth.), K. Hellmann, T. A. Connors (eds.)

The foreign Society of Chemotherapy meets each years to check growth in chemotherapy of infections and of malignant affliction. each one assembly will get greater to surround the extension of chemotherapy into new components. In a few cases, enlargement has been speedy, for instance in cephalosporins, pen­ icillins and blend chemotherapy of melanoma - in others sluggish, as within the box of parasitology. New difficulties of resistance and untoward results come up; aid of host toxicity with out lack of antitumour task through new components occupies extensive recognition. the enhanced effects with melanoma chemotherapy, es­ pecially in leukaemias, are resulting in a better occurrence of serious an infection in sufferers so handled, pharmacokinetics of gear in common and diseased topics is receiving expanding consciousness in addition to comparable difficulties of bioavailability and interactions among medicines. in the meantime the assault on a number of the significant bacterial infections, corresponding to gonorrhoea and tubercu­ losis, that have been one of the first infections to believe the influence of chemotherapy, nonetheless stay significant international difficulties and are actually less than assault with new brokers and new tools. From this large box and the 1,000 papers learn on the Congress we have now produced lawsuits which mirror the range and vigor of analysis during this very important box of medication. It was once impossible to incorporate the entire papers provided on the Congress yet we have now tried to incorporate so much points of cur­ lease growth in chemotherapy.

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On the other hand, the risk shoUld not be overrated, since experience has shown that latency periods of 10 years or even more are to be expected. Cancer is a vital indication which necessarily implies certain risks. Even radiation therapy may eventually induce cancer, and surgery is not at all free from any risk. Therefore the demand for rigid principles of indication equally applies to all three types of treatment. The use of suitable chemotherapeutic agents in inoperable and chemosensitive systemic tumour conditions is not only justified, but urgenly indicated for vital grounds.

For this purpose it is important to use a clear and simple test for each particular action, which should simulate the physiopathological and clinical conditions as closely as possible. In the pharmacological studies on cytostatics, this has not yet been adequately achieved so far. For instance, a short-term inhibition of tumour growth observed in the experimental animals does not allow an adequately safe assessment of the drug's curative action. Clear-cut and fully reproducible results were only obtained when we used the animals' definite cure as a yardstick, which is considered to be reliable in rats whenever the animals remain free from tumours for a period of 90 days.

6. 1 1 50~ 75 Z o:sL---------- --------r f41~95 90 99 X m '"...... " en ~ IX! g. leucotoxicity or immunosuppression of a certain curative dose, for instance the CD 95 (Fig. 6). If the danger coefficient of a newly developed agent is related to that of a well-known standard, the risk of organotropic toxic complications can be easily assessed for any curative effect. 0 Pharmacotherapeutic assessment of cancerotoxic agents Pharmacotherapeutic assessment of antitumour agents, just as of any other drugs, can be divided into 3 stages: (1) Primary screening (2) Special pharmacological and toxicological characterization (3) Preclinical pharmacology These 3 stages should not be considered apart from each other as independent units, but they should continuously increase the relevant information about the drug's therapeutic and toxic properties with regard to its clinical use.

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