Chapter 1 Chairman's establishing feedback (pages 1–2): W. Modell
Chapter 2 Pharmacological variations, Qualitative and Quantitative, among guy and different Species (pages 3–23): Arnold D. Welch
Chapter three separately diverse Responses to medicinal drugs in accordance Toage, intercourse and useful or Pathological nation (pages 24–54): James R. Gillett
Chapter four styles of Metabolic Disposition of gear in guy and different Species (pages 55–70): Adrien Albert
Chapter five styles of Excretion of gear in guy and different Species (pages 71–90): R. T. Williams
Chapter 6 Anaemia, Leucopenia and Thrombocytopenia as a result of Drug hypersensitive reaction: the significance of Cross?Reactions (pages 91–110): J. Dausset and A. Barge
Chapter 7 The Predictive price of Animal checks on the subject of medicines Affecting the Cardiovascular procedure in guy (pages 111–124): J. W. Black
Chapter eight Predictable and Unpredictable Responses to medications: the Kidney (pages 125–137): R. H. Kessler
Chapter nine The Prediction of Hepatotoxiclty as a result of healing brokers in guy (pages 138–154): Sheila Sherlock
Chapter 10 Predictable and Unpredictable Responses to medications: the worried method (pages 155–180): Leo E. Hollister
Chapter eleven Drug allergic reaction (pages 181–187): G. B. West
Chapter 12 Idiosyncrasy and Intolerance (pages 188–219): Bernard B. Brodie
Chapter thirteen Pharmacogenetics and the Predictability of Drug Responses (pages 220–246): W. Kalow
Chapter 14 Chairman's remaining feedback (pages 247–250): W. Modell
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Extra info for Ciba Foundation Symposium - Drug Responses in Man
In relating variations in the pharmacological and toxic actions of drugs to differences in drug metabolism, it is important to determine whether the actions are caused by the parent drug or by its metabolites. When none of the metabolites is active, only variations in the rate of metabolism and elimination need be considered. For example, the action of pentobarbitone depends on its rate of metabolism and not on whether it is hydroxylated in the penultimate or ultimate position of the side chain.
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I shall discuss some of the factors that affect the rate of metabolism of drugs. Among these factors are age, sex and the dietary and physiological states of the animals. Prior administration of various substances to animals or man may also alter drug metabolism by increasing or decreasing the activities of enzymes which metabolize drugs. The interplay of these various factors in controlling the concentration of drugs in plasma, and hence their therapeutic effects, will be described. MECHANISMS OP DRUG MBTABOLISM A number of drugs have been designed to combine with specific receptors in the body.