By Michael F Greene, Robert K. Creasy MD, Robert Resnik MD, Jay D. Iams MD, Charles J. Lockwood MD, Thomas Moore MD
On your perform, you require complex wisdom of the obstetrical, scientific, genetic and surgical issues of being pregnant and their results at the mom and fetus. With either simple technology and medical details, six new chapters, and an up to date colour layout, you would like glance no extra than the sixth version of this long-time most sensible vendor. thoroughly revised and up to date, this well known reference now's an entire on-line source due to the further performance of professional seek advice - www.expertconsult.com.Includes either easy technology and medical info to provide you complete wisdom of the biology of pregnancy.Acts as a very good source for OB/GYNs learning for his or her Maternal-Fetal drugs forums - and for practitioners who want easy access to functional information.Features a significant other site at www.expertconsult.com with absolutely searchable text.Provides an up to date and targeted reference record to maintain you modern at the criteria of care in maternal-fetal drugs today.Keeps you present with a brand new part: problems on the Maternal-Fetal Interface.and 6 new chapters: Biology of Parturition, Developmental Origins of future health and illness, Intrapartum overview of Fetal health and wellbeing, Pathogenesis of Pre-term beginning, Maternal and Fetal Infectious problems, and Benign Gynecological stipulations of Pregnancy.Features over 50% new authorship with elevated concentrate on foreign perspectives.Includes the subsequent scorching themes in Maternal-Fetal medication: o Biology of Parturitiono Fetal Growtho Prenatal Genetic Screening and Diagnosiso Fetal Cardiac Malformations and Arrhythmias o Thyroid sickness and being pregnant o administration of melancholy and Psychoses while pregnant and the PuerperiumFocuses on proof established drugs, the present most sensible perform in MFM for diagnosing and treating excessive hazard pregnancies.Includes new illustrations and an up-to-date, colour design.Your buy entitles you to entry the website till the subsequent variation is released, or until eventually the present variation isn't any longer provided on the market by means of Elsevier, whichever happens first. If the following version is released under 365 days after your buy, you may be entitled to on-line entry for 365 days out of your date of buy. Elsevier reserves the proper to provide an appropriate substitute product (such as a downloadable or CD-ROM-based digital model) may still entry to the website be discontinued.
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Additional resources for Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice: (Expert Consult - Online and Print) (MATERNAL-FETAL MEDICINE (CREASY)), 6th Edition
5 21 85 16 95 94 — A single isolated malformation or a mental retardation without an associated physical malformation signiﬁcantly reduces the likelihood of a chromosome abnormality. Disorders of the sex chromosomes are more likely to be associated with phenotypic ambiguity of the external genitalia and perhaps slight abnormality in growth pattern. Certainly, any newborn manifesting sexual ambiguity should undergo a chromosome analysis. , adrenogenital syndrome), the identiﬁcation of sex genotype by chromosome analysis will assist attending physicians in their decisions about therapy and counseling for the parents.
19,20 High heritability does not imply the action of a single gene but rather a greater contribution of genes compared with environmental or stochastic factors for the characteristic being studied. Disorders (or susceptibility to them) may be inherited as monogenic, oligogenic, or polygenic in a given family. A disease with high heritability may also be inherited in different families through different genes. A disease caused by any of several mutations in the same gene is said to show allelic heterogeneity.
There is an approximately 10% incidence of chromosomal abnormalities in such individuals, compared with less than 1% for liveborn infants surviving the neonatal period. The likelihood of ﬁnding a chromosome mutation is increased signiﬁcantly if intrauterine growth retardation or phenotypic birth defects are present. Fertility Problems In women presenting with amenorrhea and couples presenting with a history of infertility or spontaneous abortion, the incidence of chromosomal defects is between 3% and 6%.