Cytokines (Growth Factors & Cytokines in Health & Disease) by C. Bondy, D. LeRoith

By C. Bondy, D. LeRoith

Progress in molecular know-how lately has prompted an grand progress of knowledge approximately intercellular peptide messengers and their receptors. The variety of characterised interleukins for instance numbered simply 3 six years in the past and now there are a minimum of sixteen. moreover, the variety of defined neutrophic peptides is round 30 and the variety of receptors is ever expanding. simply because lots of those new peptide ligands and receptors have been pointed out through "reverse genetic" ideas the knowledge in their organic roles falls at the back of the information in their molecular buildings. in spite of the fact that a brand new pressure of sensible stories has began and animal versions are constructed making an allowance for extra study into the organic roles of those messenger peptides and their receptors. Cytokines, the subject of this quantity, describes a bunch of proteins pointed out essentially in the immune and hematopoietic platforms. As many cytokines as attainable are integrated in addition to their receptors delivering the reader with a consultant to an ever-changing box of medical research.

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C. , 1987; Sen and Lengyel, 1992). , 1992). Other actions on viral transcription or RNA replication are probably also mediated by IFN-induced proteins, an example being the Mx proteins inhibiting influenza replication specifically in mouse cells (Horisberger, 1992), but the functions of many of the induced proteins is still unclear. It is likely that different induced proteins act on different viruses, some probably also causing membranal changes which impair assembly of certain viruses, among which retroviruses and VSV, or impair virus uncoating.

1994). Type I Interferon Receptor 419 Hu-IFN-o(B2 (EMCV) Figure 10. Antiviral activity of Hu-IFN-aB2. The experiments were performed as described in the legend to Figure 9 except that Hu-IFN-aB2 was substituted for Hu-IFN-oA. The data for 16-9 and KO cells are maximal values as the endpoint titer was > 10,000 units/ml. Data from Cleary et al. (1994). Hu-IFN-a to stimulate MHC class I antigens were successfully reconstituted. Thus, the Hu-BRN-aRl subunit plays a critical role in the functional human Type IIFN receptor complex components of which are encoded on this YAC.

1991). Human interferon omega (co) binds to the a/p receptor. J. Biol. Chem. 266, 19875-19877. M. (1967). Interferon binding: The first step in establishment of antiviral activity. Science 156, 1760-1761. D. (1989). Cloning and expression of the cDNA for the murine interferon-Y receptor. Proc. Natl. Acad. Sci. USA 86, 8497-8501. R. (1986). Differential human interferon alpha receptor expression on proliferating and non-proliferating cells. Eur. J. Biochem. 157, 187-193. , & Aguet, M. (1989). Cloning of Murine interferon-y receptor cDNA: Expression in human cells mediates high affinity binding but is not sufficient to confer sensitivity to murine interferon-Y- Proc.

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