Cytokines in the Genesis and Treatment of Cancer by Richard M. Peek Jr. MD (auth.), Michael A. Caligiuri MD,

By Richard M. Peek Jr. MD (auth.), Michael A. Caligiuri MD, Michael T. Lotze MD (eds.)

Cytokines within the Genesis and remedy of Cancer offers a accomplished photograph of the twin function of host responses in selling and inhibiting tumor development. This quantity represents a major research into the rising intersection of melanoma biology and melanoma immunology. Divided into 4 sections, the volume’s first 3 components specialize in cytokines within the genesis of melanoma. the ultimate part describes the striking growth — either in animal versions and people — in demonstrating using cytokine or anticytokine remedies for the prevention and therapy of melanoma. Cytokines within the Genesis and therapy of Cancer brings jointly a powerful array of across the world unique investigators who're dedicated to the examine of cytokines and melanoma. jointly, they produce an insightful, entire dialogue of cytokines and melanoma that might function the fitting reference for all these operating within the field.

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Boncristiano M, Paccani SR, Barone S, et al. The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms. J Exp Med 2003; 198:1887–1897. 33. Sundrud MS, Torres VJ, Unutmaz D, Cover TL. Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion. Proc Natl Acad Sci U S A 2004; 101:7727–7732. 34. Zabaleta J, McGee DJ, Zea AH, Hernandez CP, Rodriguez PC, Sierra RA, Correa P, Ochoa AC.

From: Cancer Drug Discovery and Development, Cytokines in the Genesis and Treatment of Cancer Edited by: M. A. Caligiuri and M. T. , Totowa, NJ 27 28 Part I / Infectious Agents, Cytokines, and Cancer Table 1 HTLV-1 Associated Diseases Strongly associated diseases Adult T-cell leukemia/ lymphoma (ATLL) HTLV-1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) Aggressive T-cell malignancy—monoclonal expansion of CD3+/CD4+/CD8–/CD25+/HLADR+ T-cells (5). One to 5% of early HTLV-1 infected individuals, develop ATLL after a prolonged incubation period ~ 20–30 years (30,32).

Watanabe Y, Kurata JH, Mizuno S, et al. Helicobacter pylori infection and gastric cancer. A nested case-control study in a rural area of Japan. Dig Dis Sci 1997; 42:1383–1387. 11. Siman JH, Forsgren A, Berglund G, Floren CH. Association between Helicobacter pylori and gastric carcinoma in the city of Malmo, Sweden. A prospective study. Scand J Gastroenterol 1997; 32:1215–1221. 12. Sipponen P, Kosunen TU, Valle J, Riihela M, Seppala K. Helicobacter pylori infection and chronic gastritis in gastric cancer.

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