Dendritic Cells in Cancer by Jessica Chu, Russell D. Salter (auth.), Russell D. Salter,

By Jessica Chu, Russell D. Salter (auth.), Russell D. Salter, Michael R. Shurin (eds.)

Significant positive factors of melanoma are suppression and redirection of the immune reaction, which permit for tumor improvement and progress within the formerly immune efficient host. primary to improvement of immune responses are dendritic cells, and unsurprisingly those cells are strongly impacted by way of tumors and components derived from them, in addition to through different stipulations linked to tumor development or melanoma remedies. additional, as many of the frontline innovations for therapy of melanoma contain immunotherapy with ex vivo cultured or in vivo modulated dendritic cells, it turns into crucial to appreciate how dendritic cells engage with and are tormented by the tumor microenvironment. "Dendritic Cells in Cancer," edited by way of Michael R. Shurin and Russell D. Salter, provides thorough analyses of the advanced biology of the tumor-dendritic phone dating, and provides insights into how melanoma remedies may gain advantage from furthering our knowing during this area.

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Deavers, M. , Sahin, A. , Lewis, D. , El-Naggar, A. K. and Clayman, G. L. 2000. In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. , Shimosato, Y. and Suemasu, K. 1985. T-zone histiocytes in adenocarcinoma of the lung in relation to postoperative prognosis. Cancer 56:2651–2656 Gabrilovich, D. , Chen, H. , Girgis, K. , Cunningham, H. , Meny, G. , Kavanaugh, D. and Carbone, D. P. 1996a. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells.

Thomson, A. , Sariola, H. and Saarinen-Pihkala, U. M. 2004. Dendritic cell subsets in childhood and in children with cancer: relation to age and disease prognosis. Clin Exp Immunol 135:455–461 Van Haelst, U. J. 1969. Light and electron microscopic study of the normal and pathological thymus of the rat. 3. A mesenchymal histiocytic type of cell. Z Zellforsch Mikrosk Anat 99:198–209 Van Voorhis, W. , Hair, L. S. and Steinman, R. M. 1983a. Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication.

1997) revealed that melanoma-derived factors convert DC-antigen-presenting cell function to tolerance induction against tumor tissue, changing antitumor DC to ‘‘silencers’’ of antitumor immune responses. These and other early reports supported the notion that inadequate presentation of tumor antigens by host DC is one potential mechanism of tumormediated inhibition of DC function as antigen-presenting cells (Fig. 1B). At the same time, it was shown that tumor-derived factors might suppress differentiation and functional maturation of DC (Gabrilovich et al.

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