By A. Ponte-Sucre (auth.), Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves (eds.)
One of the most difficulties referring to healing instruments for the therapy of parasitic ailments, together with leishmaniasis, is that a few box parasites are evidently proof against the classical medicinal drugs; also, present remedies might pick out parasites at risk of be proof against the utilized medications. those gains are (at least in part) liable for the disappointing patience of the illness and resultant deaths world wide. This e-book presents a finished view of the pathology of the disorder itself, and of parasitic drug resistance, its molecular foundation, results and attainable remedies. Scientists either from educational fields and from the all for biomedical examine and drug layout, will locate during this booklet a useful and primary advisor that conveys the information had to comprehend and to enhance the luck in battling this ailment worldwide.
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Additional resources for Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments
2010). For instance, two of the species comprised in the L. donovani complex, namely, L. chagasi and L. archibaldi, are not supported by any molecular analyses. As already discussed above, strains of L. chagasi are undistinguishable from strains of L. infantum and should therefore be regarded as South American strains of L. infantum (Mauricio et al. 2000; Kuhls et al. 2011). Molecular studies have also shown that L. archibaldi is not a valid species (Lukes et al. 2007) and that only a single-nucleotide polymorphism in the glutamate oxaloacetate transaminase gene underlies the different MLEE phenotype (Jamjoom et al.
Parasitol 135:567–574 Floch H (1954) [Leishmania tropica guyanensis n. , cause of cutaneous leishmaniasis in the Guinanas and Central America]. Publ Inst Pasteur Guyane Fr Inini 15:1–4 Fraga J et al (2010) Phylogeny of Leishmania species based on the heat-shock protein 70 gene. Infect Genet Evol 10:238–245 Gelanew T et al (2010) Inference of population structure of Leishmania donovani strains isolated from different Ethiopian visceral leishmaniasis endemic areas. PLoS Negl Trop Dis 4:e889 Grimaldi Jr G et al (1992) Description of Leishmania equatorensis sp.
The evolution of Paraleishmania is not yet fully understood. The great genetic difference between the Euleishmania and Paraleishmania (Cupolillo et al. 2000) would favor an ancient divergence between these groups. It has been speculated that the two sections of the genus Leishmania became separated before the split of Gondwana (Momen and Cupolillo 2000). The same authors concluded that, with the separation of Gondwana in the Mesozoic, the Euleishmania evolved into 28 G. Sch€ onian et al. L. (Leishmania) in Africa and L.