Drug Transporters by Jörg König (auth.), Martin F. Fromm, Richard B. Kim (eds.)

By Jörg König (auth.), Martin F. Fromm, Richard B. Kim (eds.)

It is more and more well-known that numerous transporter proteins are expressed during the physique and make sure absorption, tissue distribution, biliary and renal removing of endogenous compounds and medicine and drug results. This ebook will supply an outline at the transporter households that are most crucial for drug remedy. so much chapters will specialize in one transporter relatives highlighting tissue expression, substrates, inhibitors, knock-out mouse versions and medical studies.

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Sample text

4 Inhibitors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Drug/Drug Interactions: Pharmacogenomics . . . . . . . . . . . . . . . . . . . . 88 10 Organic Anion Transporter 7 (OAT7, Gene Name SLC22A9) . . . . . . . . . . . . . 1 Cloning, Structure, Tissue Distribution, Localization . . . . . . . . . . . . . . . 2 Substrates (Shin et al.

31 32 32 34 36 36 37 39 49 50 51 52 52 52 53 53 54 54 58 58 58 58 58 59 59 60 60 61 69 69 71 G. C. F. B. 1007/978-3-642-14541-4_2, # Springer-Verlag Berlin Heidelberg 2011 29 30 G. C. Burckhardt 5 Organic Anion Transporter 4 (OAT4, Gene Name SLC22A11) . . . . . . . . . . . . . 1 Cloning, Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Tissue Distribution of mRNA . . . . . . . . .

83 7 Organic Anion Transporter 10 (OAT10/ORCTL3, Gene Name SLC22A13) . . . . . . 1 Cloning, Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Tissue Distribution of mRNA . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Immunolocalization of OAT10 Protein, Gender Differences . . . . . . . . . . . 4 Substrates . . . . . . . . . . . . . . .

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