Fast Neutrons and High-LET Particles in Cancer Therapy by S. Vynckier, R. Schmidt (auth.), Prof. Dr. Rita

By S. Vynckier, R. Schmidt (auth.), Prof. Dr. Rita Engenhart-Cabillic, Prof. Dr. André Wambersie (eds.)

Fast neutron remedy used to be brought in London in 1970. The publication provides an summary of the advancements of the previous 28 years, assesses the result of speedy neutron remedy, and studies the compiled medical facts world wide. The authors describe the radiobiological profile of the neutron beams and review the neutron RBE for secondary melanoma induction, they introduce heavy-ion remedy, which mixes excessive actual selectivity with the organic merits of high-LET radiation for a few tumor varieties, and eventually they describe the very fresh advancements in Boron Neutron seize remedy (BNCT).

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The set of parameters has to be obtained from dose measurements and dose distributions for different field-sizes and SSDs. According to a well-konwn TAR/TPR method for photons, equivalent models for neutrons are available. The absorbed dose is separated into a primary component, stated as TAR/TPR for field-size zero, and the scatter component, stated as scatter-air- or scatter-phantom-ratio. For photons TAR/TPR values are generally independent of SSD whereas for neutrons an additional correction may be necessary to obtain agreement at different SSDs.

L984). Figure 16 illustrates a typical variation of the gamma component as a function of depth in different neutron beams. Treatment Planning for Neutron Therapy For the application of neutrons in radiotherapy the distribution of absorbed dose in the patient has to be determined. As different components in a neutron field have different RBEs, the total absorbed dose needs to be separated 25 • ~ 20 • 15 0 p(65l+Be 0 p(75)+Bc ~ 5 "'- 6u d(l4)+Uc d(20)+Be • d(SO)+Be l> p(34)+Re 0 p(4S)+lle 10 '" ~ &J 5 0 0 5 10 15 20 25 depth in water (em) Fig.

If the decrement lines are not straight, the accuracy is determined by the number of profile scans and the curvature of the decrement lines. Another approach uses generating functions, either purely empirical or based on physical and geometrical properties. The set of parameters has to be obtained from dose measurements and dose distributions for different field-sizes and SSDs. According to a well-konwn TAR/TPR method for photons, equivalent models for neutrons are available. The absorbed dose is separated into a primary component, stated as TAR/TPR for field-size zero, and the scatter component, stated as scatter-air- or scatter-phantom-ratio.

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