By Arthur S. Levine (auth.), Ronald H. Goldfarb Ph.D. (eds.)
Individual neoplastic illnesses frequently exhibit discrete progress direct impact of tumor metastases or to antagonistic outcomes styles topic to many changes based on the linked to those healing modes (e.g., problems degree of the ailment, the species concerned and the tumor form of immunosuppression which may end up in mortality coming up involved. basic neoplasms are easier to regard in from infectious disease). distinction to secondary neoplasms. the executive form of secon it truly is for this reason particularly transparent that there's a the most important desire for dary neoplastic progress, metastasis, is usually relatively new equipment for the detection of micrometastases and the improvement of latest modalities for the remedy of estab much less good understood. Phylogenetically, metastasis attains its maximum point of improvement within the mammal and is healthier lished metastases. it's most likely that such modalities needs to identified in guy, yet remains to be faraway from being understood. conquer tumor heterogeneity and drug resistance to yield new healing modalities with more suitable margin of security the method of melanoma development and development, from the initiation of neoplastic transformation of standard cells to the and efficacy over at the moment on hand anti-neoplastic drugs.
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140. 141. 142. 143. 144. 145. 146. 147. 148. Skipper HE: Reasons for success and failure in treatment of murine leukemia with the drugs now employed in treating human leukemias. Cancer Chemotherapy (vol. I). Ann Arbor, Michigan: University Microfilms Internatl, 1978 Siamon DJ, deKernion JB, Verma 1M, Cline MJ: Expression of cellular oncogenes in human malignancies. Science 224:256-62, 1984 Smith RL: Recorded and expected mortality among the Japanese of the United States and Hawaii, with special reference to cancer.
Usage of vertebrate cell, tissue and organ culture terminology. In Vitro 15:649-653, 1979 Siegal GP, Thorgeirsson UP, Russo RG, Wallace OM, Liotta LA, Berger SL: Interferon enhancement of the invasive capacity of Ewing sarcoma cells in vitro. Proc Natl Acad Sci USA 79:4064-4068, 1982 Stromberg K: The human placenta in cell and organ culture. Methods Cell BioI 21:227-252, 1980 Stuermer VM, Stein RJ: Cytodynamic properties of human endometrium. II. Cultivation and behavior of stromal cells of human decidua in vitro.
II. Cultivation and behavior of stromal cells of human decidua in vitro. Am J Obstet GynecoI60:1332··1338, 1950 Stuermer VM, Stein RJ: Cytodynamic properties of the human endometrium. V. Metabolism and the enzymatic activity of the human endometrium during the menstrual cycle. Am J Obstet GynecoI63:359-370, 1952 68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 27 Talmage DM, Dart G: A search for the optimum conditions for culturing allografts before transplantation. Gin Immunol ImmunopathoI15:314--317, 1980 Thompson D: Some further researches on the cultivation of tissues in vitro.