By Carl J. Pfeiffer (auth.), Professor Dr. Christian H. Herfarth, Dr. Peter M. Schlag (eds.)
The challenge of gastric melanoma, with its multifaceted features, bargains an instance of assorted oncological examine, which include epidemiology, pathogenesis, histo morphology, surgical and conservative remedy in its spectrum. This illness not just constitutes a fascinating and significant topic for examine, however it is additionally a problem for the practitioner as a result of its inordinately terrible diagnosis. It hence seemed a profitable job to the editors to assemble info from person specialists, to be able to achieve a topical precis of the issues bearing on gastric melanoma, in addition to to supply a survey of the growth and the healing chances during this box. This activity was once fairly attractive, as gastric melanoma has in recent years come to belong to these tumors a bit of relegated to the shadows, even though it is, regardless of its reduced fre quency in a few western international locations, nonetheless essentially the most common malignant ailments. This assortment may still emphasize the necessity for widely established wisdom of person difficulties as a prerequisite for any passable treatment of an organ tumor. it really is for this reason the first situation of this ebook to provide somebody with an curiosity in oncology with this valuable survey. The editors thank Mrs. Karin Dohmeier and Mrs. Karin Kluge from Springer-Verlag for his or her cooperation in getting ready this monograph. We expand our due to Mrs. Susanne Schenk and Mrs. Marga Wild, who contributed loads by way of her secretarial adventure for the good fortune of this quantity. lJIm,September1979 Ch. Herfarth P. Schlag desk of Contents 1 Epidemiology and Pathogenesis . . . . . . . . . . .
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Extra resources for Gastric Cancer
We have performed long-term sequential studies of MNNG- and ENNGinduced carcinogenesis in the stomach of dogs by endoscopy and biopsy . In the present paper, we wish to focus attention on correlation between experimental gastric cancer and its preceding lesions from a clinico-histopathologic viewpoint. Gastric Cancer and its Preceding Lesions in the Stomach of Dogs Material and Methods MNNG and ENNG were administered to 23 male beagle dogs, 7 - 9 months of age. lllmi with or without 4 mg/ml Tween 60 in drinking water for 35 - 63 weeks.
7. Active ulcer at the angulus in the stomach of a dog (No. 25) at the 25th week Fig. 8. Cancer at the 59th week which developed from the active ulcer shown in Fig. 7 Experimental Gastric Cancer: Pathogenesis and Clinico-Histopathologic Correlation Fig. 9 27 Fig. 10 Fig. 9. Polyp at the antrum in the stomach of a dog (No. 21) at the 78th week Fig. 10. Cancer at the 176th week which developed in the polyp shown in Fig. 9 stage to the advance stage was analyzed based on macroscopic characteristics observed by endoscopy examination.
Such severe epithelial changes could not be determined for rats after gastroenterostomy according to Roux (group c) (Fig. 4, right column). The enhancing influence of truncal vagotomy on proliferative changes in the epithelium in combination with carcinogen treatment (MNNG) is made clear by the fact that those animals, on which only a vagotomy had been performed (group e), also developed distinct adenomatous lesions of the mucosa as well as carcinomas, unlike the control group (Fig. 5). Compared to the vagotomized and carcinogen-treated animals oCgroup a, pyloroplasty of similarly treated animals (group d) resulted in a significant decrease of epithelial proliferation despite vagotomy, matching the results obtained for the control group exposed to carcinogen.