By William C. Raschke (auth.), Stewart Sell, Britta Wahren (eds.)
The skill to diagnose melanoma via easy size of a serum or tissue' 'marker" has been a aim of scientific technology for a few years. there's plentiful facts that tumor cells are assorted from common cells and professional duce ingredients that may be detected by means of at the moment on hand immuno chemical or biochemical equipment. those "cancer markers" should be se creted proteins, enzymes, hormones, fetal serum elements, monoclonal immunoglobulins, telephone floor parts, or cytoplasmic components. the aim of this ebook is to provide the present prestige of our wisdom of such melanoma markers. the 1st tumor marker pointed out through laboratory capacity was once Bence Jones protein. In a chain of lectures dropped at the Royal university of Phy sicians in London in 1846, Dr. H. Bence Jones defined stories on a urine pattern despatched to him with the subsequent be aware: "Dear Dr. Jones-The tube includes urine of very excessive particular gravity. while boiled it turns into a bit opaque . . . . and so on. " Dr. Jones stumbled on that heating of the urine after addition of nitric acid ended in formation of a heavy precipitate; acid advert dition can have been required to carry the urine to pH 4-6 at which Bence Jones proteins usually tend to precipitate while heated. This urinary pre cipitate used to be linked to a bone ailment termed "mollities ossium. " [H. Bence Jones, Papers on Chemical Pathology, Lecture III. Lancet 2, 269-274 (1847)].
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Since the presence of Fc receptors provided an initial means to study T lymphocyte subsets, extensive (and sometimes conflicting) literature has recently been generated. , 1978). With increasing studies being performed using Fc receptors to characterize subsets, difficulties in the standardization of reagents and techniques have become apparent. , 1977). Furthermore, interpretation of functional data may be complicated by the fact that a single subset may bear either FC-fL or Fc-" receptors at different stages of its functional development (Pichler and Broder, 1978).
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