Intensive Care Medicine: Annual Update 2006 by W. J. Wiersinga, T. van der Poll (auth.), Jean-Louis Vincent

By W. J. Wiersinga, T. van der Poll (auth.), Jean-Louis Vincent MD, PhD, FCCM, FCCP (eds.)

The replace compiles the newest advancements in experimental and scientific study and perform in a single entire reference e-book. The chapters are written via good well-known specialists within the box of in depth care and emergency drugs. it really is addressed to each person excited by inner medication, anesthesia, surgical procedure, pediatrics, in depth care and emergency medicine.

Show description

Read Online or Download Intensive Care Medicine: Annual Update 2006 PDF

Best nonfiction_9 books

Fungal Associations

This re-creation of Fungal institutions specializes in mycorrhizas, lichens and fungal-bacterial symbioses. it's been thoroughly revised, up-to-date and elevated. popular specialists current thorough studies and speak about the newest findings on molecular interactions among fungi and vegetation or micro organism that bring about morphological changes and novel homes within the symbionts.

Social Bioarchaeology

Illustrates new methodological instructions in examining human social and organic version bargains a big selection of study on prior populations around the world Explains the significant gains of bioarchaeological learn by way of key researchers and confirmed specialists world wide content material: bankruptcy 1 construction a Social Bioarchaeology (pages 1–11): Sabrina C.

HIV Protocols

In HIV Protocols, Nelson Michael and Jerome Kim have prepared a suite of state of the art ideas crucial for learning the molecular biology, virology, and immunology of the HIV virus. The tools hide a large diversity of analysis pursuits, together with quantitation of viral genomes, HIV promoter functionality, B-cell epitope mapping, viral coreceptor utilization, and measurements of T-cell functionality.

Interleukin Protocols

Interleukins, a kinfolk of proteins that keep watch over immunity and irritation through the physique, also are excited by autoimmune illness (rheumatoid arthritis, a number of sclerosis, and asthma); are implicated in such different stipulations as melanoma, myocardial infarction, and melancholy; and feature price within the prognosis and analysis of many ailments.

Additional resources for Intensive Care Medicine: Annual Update 2006

Example text

Reactive oxygen and nitrogen species (ROS/RNS): origin and metabolism ROS/RNS molecule Main Source Enzymatic Defense System Products z Superoxide (O·± 2 ) Activated phagocytes Discharge of electrons from the electron transport chain Xanthine oxidase Flavoenzymes Superoxide dismutase (SOD) H2O2 + O2 H2O2 z Hydrogen peroxide (H2O2) Product of SOD NADPH-oxidase (neutrophils) Glucose oxidase Xanthine oxidase Glutathione peroxidase Catalases Peroxiredoxins (Prx) H2O + GSSG H2O + O2 H2O z Hydroxyl radical (HO·±) From O·± 2 and H2O2 via transition metals (Fe or Cu) GSNO z Nitric oxide (NO) Nitric oxide synthases Glutathione/TrxR z Peroxynitrite (ONOO-) Product from NO + O·± 2 triggering DNA single strand breaks Poly-(ADP-Ribose) Polymerase (PARP) SOD: superoxide dismutase; GSSG: oxidized glutathione; GSNO: S-nitrosoglutathione naling and redox regulation [12, 13].

To make things more complicated, responsiveness of TLR2 to LPS has also been described [20]. In this respect, it is interesting that pretreatment with bacterial lipoprotein, a TLR2 ligand, protected otherwise highly susceptible TLR4-deficient C3H/HeJ mice from Salmonella typhimurium induced Gram-negative sepsis via enhanced bacteria clearance [21]. The relationship between TLR expression and human sepsis may be complex, as is suggested by some recent studies in septic patients [22, 23]. Increased cell surface (neutrophils and monocytes) expression and increased mRNA levels of both TLR2 and TLR4 are seen in septic patients [22, 23].

Most likely, the increased susceptibility to Gram-negative sepsis is caused by a diminished and thus inadequate response to LPS. Further associations have been found between the TLR2 Arg753Gln polymorphism and increased susceptibility to sepsis caused by Staphylococcus aureus [41]. On the other hand, in a series of 1047 patients with culture proven meningococcal disease, the TLR4 Asp299Gly polymorphism was ± contrary to the hypothesis ± not associated with host susceptibility or severity of disease [38].

Download PDF sample

Rated 4.65 of 5 – based on 40 votes