Interaction of Immune and Cancer Cells by Daniela Spano, Massimo Zollo (auth.), Magdalena Klink (eds.)

By Daniela Spano, Massimo Zollo (auth.), Magdalena Klink (eds.)

The tumor atmosphere is a dynamic community that comes with melanoma cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and receptors. the purpose of this ebook is to summarize the function of those elements, in particular immune cells, in tumor suppression and/or development and describe intimately why tumor cells can live to tell the tale and unfold regardless of the antitumor reaction of immune cells. considering immunotherapy is an enticing method of melanoma remedy, this e-book additionally presents info at the major techniques: monoclonal antibodies and adaptive T phone immunotherapy, with a spotlight on contemporary human scientific trials.

The ebook presents a state of the art, accomplished assessment of immune cells in melanoma and is an essential source for scientists and doctors operating and/or lecturing within the box of melanoma learn and immunology. ​

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Example text

1 Epithelial Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Basement Membrane and Extracellular Matrix . . . . . . . . . . . . . . . . . . 3 TME: The Immune Components, Chronic Inflammation, Wound Healing, and Tumor Progression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 EMT and TGF-β . . .

3 TME: The Immune Components, Chronic Inflammation, Wound Healing, and Tumor Progression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 EMT and TGF-β . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 TGF-β Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Osteopontin and EMT . . .

Elaborate molecular cascades coordinating transcription factor activation, expression of specific cell-surface proteins, reorganization and expression of cytoskeletal proteins, production of ECM-degrading enzymes, and changes in the expression of specific microRNAs are required to complete EMT. Cancer cells undergo EMT to invade and metastasize. Importantly, cancer cells may adopt mesenchymal characteristics to differing extents, with some cells retaining some epithelial traits while others become fully mesenchymal.

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