Intracellular Signal Transduction: The JAK-STAT Pathway by Andrew F. Wilks

By Andrew F. Wilks

This ebook is the 1st one written in regards to the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases totally required for mobile signalling downstream of non-catalytic cytokine receptors (amongst others). those molecules are parts in pathways applying the STAT (Signal Transducers and Activators of Transcription) transcription components. the elemental parts of the JAK/STAT pathway are coated intimately, and the centre piece of the ebook is a guided journey of the pathway itself. an enticing addition to the publication is the bankruptcy at the use of Drosophila melanogaster as a genetic method to probe the pathway on the entire organism point. The publication is focused to researchers who've an curiosity in intracellular signalling.

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The intracellular domain of ~c chain possesses both a Box 1 and Box 2 homology domain. The 13c chain of the IL-3/IL-5/GM-CSF-receptor system is the signal transducing chain for each of these a-chains. " In the mouse system, this same chain is known as AIC2B. 130 Interestingly, in the mouse system, the IL-3-Ra combines not just with AIC2B, but also with a second, related receptor known as AIC2A. 131 AIC2A and AIC2B are 91 o/o identical at the amino acid level. There does not appear to be a similar duplication of the IL-3-R~ in the human system.

The CNTF-R a is not a transme mbrane protein itself, rather it is membrane associated via a glycosyl-phosphoinositol linkage. 1 The similar range of cellular responses elicited by both LIF and CNTF is thus due to the commo n use of signal transduc tion chains by both of these cytokines. 122 •123 Conversely, the limited spectrum of biological activities elicited by CNTF is most likely to be due to the restricted pattern of expression of the CNTF- R. This fact has made feasible the intrigui ng possibility of making "designer cytokine s" wherein CNTF- Ra can be targeted to particul ar tissue whereupon a phenoto pic "LIF" response can be elicited by CNTF administration (G.

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