By G. Mathé (auth.), Georges Mathé, Roy Weiner M.D. (eds.)
G.MATHE Institut de Cancerologie et d'Immunogenetique (INSERM et organization Claude-Bernad), H6pital Paul-Brousse and Institute Gustave-Roussy, Villejuif twenty years in the past, the most, if not just item of the melanoma therapist used to be to influence entire surgical exeresis or radiotherapeutic destruction of an area tumor, or to procure, by way of chemotherapy, an "apparently whole regression" of a neighborhood or disseminated neoplasia. this day it really is discovered that (a) on the time of the operation or radiotherapy, sufferers in each 3 wearing an it seems that localized tumor have a number of melanoma cells outdoors the realm the place the tumor turns out localized; (b) whilst "apparently whole regression" or maybe an "apparently whole remission" is triggered via chemotherapy, no longer the entire neoplastic cells were eliminated. In either instances an imperceptible residual neoplasm persists, the expansion of that allows you to in the end make it perceptible back, giving upward push to metastasis or to a systemic or localized relapse. there's therefore an pressing desire for a brand new strategy in a position to killing the final telephone or cells. Our experiments in mice at the effectiveness of energetic immunotherapy, which consists of the manipulation of the immune equipment, have proven that this remedy is ready to kill all of the cells, all the way down to the final phone of a given leukemia, only if the entire variety of cells doesn't exceed a number of thousand [1, 2].
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I want to thank all my co-workers who've collaborated with me, from 1963 before, in organic and medical learn within the box of melanoma energetic immunotherapy, of its immuno prevention and immunorestoration. they are going to usually be quoted during this booklet. i'm quite thankful to those that have helped me to write down it by way of reviewing a few chapters: D.
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Finally, decreased immune responsiveness is, at least in part, related to the extent of prior therapy. This is true for chemotherapy, radiotherapy, and surgery. Patients who have had extensive prior therapy for their malignancy tend to have fewer responses than previously untreated patients. Thus, we are not sure which is the cart and which is the horse in the relationship of poor immune responsiveness and poor prognosis. Since most human tumors have been shown to have tumor-specific antigens and to induce tumor-specific immune responses, these considerations are very important.
Of patients exhibiting positive or normal immunological response. b No. of patients exhibiting negative or subnormal response. Tables 3, 4, and 5 show the relevant data from the study in which immunocompetence and prognosis were related in patients with acute leukemia. These patients included 16 receiving COAP1, 5 receiving POMP, one receiving cytosine arabinoside and thioguanine simultaneously, 2 receiving cytosine arabinoside, thioguanine and cytosine arabinoside sequentially, and one receiving thioguanine alone.
An intrinsic lymphocyte defect , a defect in marcophage number or function  and the presence or absence of immunosuppresive serum factors  have all been advanced as possible etiologic factors. Irrespective of etiology, modern cancer management and progress in therapeutic research must be based on these factors. We have summarized our past work in this field and attempted to synthesize it here. In addition we present new data on a study of immunocompetence and prognosis in a consecutive series of 51 patients with acute leukemia.