Ion channels as therapeutic targets. Part A by Rossen Donev

By Rossen Donev

Ion Channels as healing Targets is the most recent quantity within the renowned Advances in Protein Chemistry and Structural Biology sequence, an important source for protein chemists. every one quantity brings forth new information regarding protocols and research of proteins, with every one thematically equipped quantity visitor edited by means of major specialists in a large diversity of protein-related topics.

  • Provides state-of-the-art advancements in protein chemistry and structural biology
  • Discusses using ion channels as healing targets
  • Chapters are written by way of gurus of their field
  • Targeted to a large viewers of researchers, experts, and students

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Extra info for Ion channels as therapeutic targets. Part A

Example text

The second inactivation mechanism, slow voltage-dependent inactivation (VDI, C-type inactivation), occurs on the scale of several hundred milliseconds to seconds and involves conformational changes in the selectivity filter (Catterall, 2014). The third type of inactivation, closed-state inactivation (Bean, 1981), occurs in response to small depolarizations, resulting in movement of voltage sensors in domains III and IV only—not sufficient for channel opening but enough to trigger fast inactivation (Bahring & Covarrubias, 2011; Groome, Lehmann-Horn, & Holzherr, 2011).

Similarly, in muscles, opening of acetylcholine receptors at the neuromuscular junction causes depolarizing sodium and calcium current, with consecutive opening of Nav channels and triggering of APs. 1), which initiates contraction, and rapid propagation of excitation along muscle fibers. Expression of Nav channels in myocytes appears to be a relatively recent evolutionary adaptation as in many ancient species and in smooth muscles of vertebrates APs in myocytes are provided by Cav1 channels alone (Berridge, 2008).

In the sensor—the input of the system—the energy of an environmental signal is absorbed and transformed, usually with great amplification, into voltage changes by a transducer—a device that can convert one form of energy into another. The resulting electrical signal is digitized and sent to the computer for interpretation, processing, and conditioning. Digital control commands are sent by the computer to drive peripheral devices. In the actuator, the commands are transformed back into an analog form.

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