Lung cancer by Jack A Roth; James D Cox; Waun Ki Hong

By Jack A Roth; James D Cox; Waun Ki Hong

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Extra resources for Lung cancer

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1 Epithelial Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Basement Membrane and Extracellular Matrix . . . . . . . . . . . . . . . . . . 3 TME: The Immune Components, Chronic Inflammation, Wound Healing, and Tumor Progression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 EMT and TGF-β . . .

3 TME: The Immune Components, Chronic Inflammation, Wound Healing, and Tumor Progression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 EMT and TGF-β . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 TGF-β Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Osteopontin and EMT . . .

Elaborate molecular cascades coordinating transcription factor activation, expression of specific cell-surface proteins, reorganization and expression of cytoskeletal proteins, production of ECM-degrading enzymes, and changes in the expression of specific microRNAs are required to complete EMT. Cancer cells undergo EMT to invade and metastasize. Importantly, cancer cells may adopt mesenchymal characteristics to differing extents, with some cells retaining some epithelial traits while others become fully mesenchymal.

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