MCQs for the Primary FRCA by Elfituri K., Arthurs G., Gemmell L.

By Elfituri K., Arthurs G., Gemmell L.

This e-book brings jointly examination questions from the first FRCA exam and buildings them into six perform papers.

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75 kPa increase in PaCO2 (d) is more prominent in peripheral chemoreceptors (e) is shifted to the right by sleep and morphine 27 Paper 2 24 The development of high titres of anti-D antibodies in a Rhesus-negative mother with an Rh-positive fetus (a) is due to fetal red blood cells entering the maternal circulation (b) will result in anaemia of the newborn (c) will result in jaundice of the newborn (d) is due to antigen alone entering the maternal circulation (e) always occurs before the third month of gestation 25 Regarding calcium (a) it is mainly absorbed from the stomach (b) it is absorbed from the small intestine (c) calcitonin increases the uptake of calcium into bones (d) parathyroid hormone increases plasma calcium by activating osteoblasts (e) hydroxylated vitamin D increases absorption of calcium from the gut Questions 26 The following are true when considering the control of temperature (a) it involves afferent input from cutaneous cold receptors (b) the spinal cord is a passive conductor of afferent thermal signals (c) the central control is in the hippocampus (d) vasoconstriction occurs at a core temperature of >37 C (e) shivering is activated at a specific temperature 27 Activation of receptors for ANP increases target cell (a) GTP (b) IP3 (c) cAMP (d) protein kinase A activity (e) guanylate cyclase activity 28 If the body temperature falls during a long operation (a) oxygen and carbon dioxide are more soluble in blood (b) blood viscosity is decreased (c) there is a shift of the oxygen dissociation curve to the left (d) the effect of non-depolarising drugs is reduced (e) alkalosis is a common problem 28 MCQs MCQs for the Primary FRCA 30 Gap junctions are responsible for (a) cellular polarity (b) connections between cells (c) transmission of action potentials from one fibre to another in skeletal muscle (d) rapid transmission of action potentials by Purkinje fibres (e) transmission of action potentials from one fibre to another in smooth muscle and the gastrointestinal tract Questions Pharmacology 31 Binding of drugs to plasma proteins (a) increases their pharmacological activity (b) depends on pH (c) allows rapid renal elimination of the drug (d) can be saturated at high drug concentrations (e) enhances metabolism of the drug by the liver 32 The following drugs have an oral bioavailability greater than 50% (a) atenolol (b) methadone (c) verapamil (d) gentamicin (e) propranolol 33 The (a) (b) (c) blood/gas partition coefficient is a ratio of solubilities is a dimensionless measure is proportional to the time to onset of anaesthesia MCQs MCQs for the Primary FRCA Paper 2 29 Secretion of corticotrophin (a) controls glucocorticoid production (b) controls catecholamine production (c) is increased by the secretion of a hypothalamic releasing factor (d) is suppressed by a high level of circulating glucocorticoids (e) has a circadian variation 29 (d) determines the MAC (e) is greater for sevoflurane than for isoflurane Paper 2 34 The (a) (b) (c) (d) (e) following drugs have membrane-stabilising activity propranolol atenolol esmolol disopyramide diltiazem 35 The (a) (b) (c) (d) (e) following drugs are alpha antagonists phentolamine clonidine oxycodone chlorpromazine droperidol Questions 36 The following drugs cause dilatation of the pupil when instilled into the conjunctival sac of a normal person (a) ephedrine (b) cocaine (c) timolol (d) amethocaine (e) guanethidine 37 The (a) (b) (c) (d) (e) potency of the inhalation anaesthetic agent is inversely related to MAC is related to the oil/gas partition coefficient decreases with increasing molecular weight sevoflurane is less potent than enflurane isoflurane is the least potent inhalational anaesthetic agent 38 Sevoflurane (a) is a fluorinated ether (b) has a higher blood/gas partition coefficient than isoflurane (c) causes hepatotoxicity (d) is non-pungent (e) is less vulnerable to metabolism than desflurane 30 MCQs MCQs for the Primary FRCA 39 Ketamine (a) is presented as a racemic mixture (b) is a glutamate receptor antagonist (c) directly causes sympathomimetic effects (d) is readily metabolised by hydroxylation to form nor-ketamine (e) increases uterine contractility Questions 41 The following local anaesthetic agents have a liver biotransformation (a) lidocaine (b) procaine (c) bupivacaine (d) amethocaine (e) ropivacaine 42 Cocaine (a) causes bronchoconstriction (b) causes vomiting (c) rarely causes allergic reactions (d) is excreted largely unchanged in the urine (e) competes with norepinephrine for reuptake pathways 43 Morphine is metabolised by the following mechanisms (a) glucuronide formation (b) N-dealkylation (c) acetylation (d) hydrolysis of an ester linkage (e) oxidative deamination 44 Tramadol (a) is a racemic mixture of two enantiomers (b) enhances noradrenaline neuronal uptake MCQs MCQs for the Primary FRCA Paper 2 40 Methohexitone (a) is 6 times more potent than thiopentone (b) causes excitatory movements (c) in aqueous solution has 6 parts 100 of sodium bicarbonate by weight (d) has a shorter elimination half-life than thiopentone (e) is most commonly used for electro-convulsive therapy.

P. 75 kPa increase in PaCO2 (d) is more prominent in peripheral chemoreceptors (e) is shifted to the right by sleep and morphine 27 Paper 2 24 The development of high titres of anti-D antibodies in a Rhesus-negative mother with an Rh-positive fetus (a) is due to fetal red blood cells entering the maternal circulation (b) will result in anaemia of the newborn (c) will result in jaundice of the newborn (d) is due to antigen alone entering the maternal circulation (e) always occurs before the third month of gestation 25 Regarding calcium (a) it is mainly absorbed from the stomach (b) it is absorbed from the small intestine (c) calcitonin increases the uptake of calcium into bones (d) parathyroid hormone increases plasma calcium by activating osteoblasts (e) hydroxylated vitamin D increases absorption of calcium from the gut Questions 26 The following are true when considering the control of temperature (a) it involves afferent input from cutaneous cold receptors (b) the spinal cord is a passive conductor of afferent thermal signals (c) the central control is in the hippocampus (d) vasoconstriction occurs at a core temperature of >37 C (e) shivering is activated at a specific temperature 27 Activation of receptors for ANP increases target cell (a) GTP (b) IP3 (c) cAMP (d) protein kinase A activity (e) guanylate cyclase activity 28 If the body temperature falls during a long operation (a) oxygen and carbon dioxide are more soluble in blood (b) blood viscosity is decreased (c) there is a shift of the oxygen dissociation curve to the left (d) the effect of non-depolarising drugs is reduced (e) alkalosis is a common problem 28 MCQs MCQs for the Primary FRCA 30 Gap junctions are responsible for (a) cellular polarity (b) connections between cells (c) transmission of action potentials from one fibre to another in skeletal muscle (d) rapid transmission of action potentials by Purkinje fibres (e) transmission of action potentials from one fibre to another in smooth muscle and the gastrointestinal tract Questions Pharmacology 31 Binding of drugs to plasma proteins (a) increases their pharmacological activity (b) depends on pH (c) allows rapid renal elimination of the drug (d) can be saturated at high drug concentrations (e) enhances metabolism of the drug by the liver 32 The following drugs have an oral bioavailability greater than 50% (a) atenolol (b) methadone (c) verapamil (d) gentamicin (e) propranolol 33 The (a) (b) (c) blood/gas partition coefficient is a ratio of solubilities is a dimensionless measure is proportional to the time to onset of anaesthesia MCQs MCQs for the Primary FRCA Paper 2 29 Secretion of corticotrophin (a) controls glucocorticoid production (b) controls catecholamine production (c) is increased by the secretion of a hypothalamic releasing factor (d) is suppressed by a high level of circulating glucocorticoids (e) has a circadian variation 29 (d) determines the MAC (e) is greater for sevoflurane than for isoflurane Paper 2 34 The (a) (b) (c) (d) (e) following drugs have membrane-stabilising activity propranolol atenolol esmolol disopyramide diltiazem 35 The (a) (b) (c) (d) (e) following drugs are alpha antagonists phentolamine clonidine oxycodone chlorpromazine droperidol Questions 36 The following drugs cause dilatation of the pupil when instilled into the conjunctival sac of a normal person (a) ephedrine (b) cocaine (c) timolol (d) amethocaine (e) guanethidine 37 The (a) (b) (c) (d) (e) potency of the inhalation anaesthetic agent is inversely related to MAC is related to the oil/gas partition coefficient decreases with increasing molecular weight sevoflurane is less potent than enflurane isoflurane is the least potent inhalational anaesthetic agent 38 Sevoflurane (a) is a fluorinated ether (b) has a higher blood/gas partition coefficient than isoflurane (c) causes hepatotoxicity (d) is non-pungent (e) is less vulnerable to metabolism than desflurane 30 MCQs MCQs for the Primary FRCA 39 Ketamine (a) is presented as a racemic mixture (b) is a glutamate receptor antagonist (c) directly causes sympathomimetic effects (d) is readily metabolised by hydroxylation to form nor-ketamine (e) increases uterine contractility Questions 41 The following local anaesthetic agents have a liver biotransformation (a) lidocaine (b) procaine (c) bupivacaine (d) amethocaine (e) ropivacaine 42 Cocaine (a) causes bronchoconstriction (b) causes vomiting (c) rarely causes allergic reactions (d) is excreted largely unchanged in the urine (e) competes with norepinephrine for reuptake pathways 43 Morphine is metabolised by the following mechanisms (a) glucuronide formation (b) N-dealkylation (c) acetylation (d) hydrolysis of an ester linkage (e) oxidative deamination 44 Tramadol (a) is a racemic mixture of two enantiomers (b) enhances noradrenaline neuronal uptake MCQs MCQs for the Primary FRCA Paper 2 40 Methohexitone (a) is 6 times more potent than thiopentone (b) causes excitatory movements (c) in aqueous solution has 6 parts 100 of sodium bicarbonate by weight (d) has a shorter elimination half-life than thiopentone (e) is most commonly used for electro-convulsive therapy.

P. 75 kPa increase in PaCO2 (d) is more prominent in peripheral chemoreceptors (e) is shifted to the right by sleep and morphine 27 Paper 2 24 The development of high titres of anti-D antibodies in a Rhesus-negative mother with an Rh-positive fetus (a) is due to fetal red blood cells entering the maternal circulation (b) will result in anaemia of the newborn (c) will result in jaundice of the newborn (d) is due to antigen alone entering the maternal circulation (e) always occurs before the third month of gestation 25 Regarding calcium (a) it is mainly absorbed from the stomach (b) it is absorbed from the small intestine (c) calcitonin increases the uptake of calcium into bones (d) parathyroid hormone increases plasma calcium by activating osteoblasts (e) hydroxylated vitamin D increases absorption of calcium from the gut Questions 26 The following are true when considering the control of temperature (a) it involves afferent input from cutaneous cold receptors (b) the spinal cord is a passive conductor of afferent thermal signals (c) the central control is in the hippocampus (d) vasoconstriction occurs at a core temperature of >37 C (e) shivering is activated at a specific temperature 27 Activation of receptors for ANP increases target cell (a) GTP (b) IP3 (c) cAMP (d) protein kinase A activity (e) guanylate cyclase activity 28 If the body temperature falls during a long operation (a) oxygen and carbon dioxide are more soluble in blood (b) blood viscosity is decreased (c) there is a shift of the oxygen dissociation curve to the left (d) the effect of non-depolarising drugs is reduced (e) alkalosis is a common problem 28 MCQs MCQs for the Primary FRCA 30 Gap junctions are responsible for (a) cellular polarity (b) connections between cells (c) transmission of action potentials from one fibre to another in skeletal muscle (d) rapid transmission of action potentials by Purkinje fibres (e) transmission of action potentials from one fibre to another in smooth muscle and the gastrointestinal tract Questions Pharmacology 31 Binding of drugs to plasma proteins (a) increases their pharmacological activity (b) depends on pH (c) allows rapid renal elimination of the drug (d) can be saturated at high drug concentrations (e) enhances metabolism of the drug by the liver 32 The following drugs have an oral bioavailability greater than 50% (a) atenolol (b) methadone (c) verapamil (d) gentamicin (e) propranolol 33 The (a) (b) (c) blood/gas partition coefficient is a ratio of solubilities is a dimensionless measure is proportional to the time to onset of anaesthesia MCQs MCQs for the Primary FRCA Paper 2 29 Secretion of corticotrophin (a) controls glucocorticoid production (b) controls catecholamine production (c) is increased by the secretion of a hypothalamic releasing factor (d) is suppressed by a high level of circulating glucocorticoids (e) has a circadian variation 29 (d) determines the MAC (e) is greater for sevoflurane than for isoflurane Paper 2 34 The (a) (b) (c) (d) (e) following drugs have membrane-stabilising activity propranolol atenolol esmolol disopyramide diltiazem 35 The (a) (b) (c) (d) (e) following drugs are alpha antagonists phentolamine clonidine oxycodone chlorpromazine droperidol Questions 36 The following drugs cause dilatation of the pupil when instilled into the conjunctival sac of a normal person (a) ephedrine (b) cocaine (c) timolol (d) amethocaine (e) guanethidine 37 The (a) (b) (c) (d) (e) potency of the inhalation anaesthetic agent is inversely related to MAC is related to the oil/gas partition coefficient decreases with increasing molecular weight sevoflurane is less potent than enflurane isoflurane is the least potent inhalational anaesthetic agent 38 Sevoflurane (a) is a fluorinated ether (b) has a higher blood/gas partition coefficient than isoflurane (c) causes hepatotoxicity (d) is non-pungent (e) is less vulnerable to metabolism than desflurane 30 MCQs MCQs for the Primary FRCA 39 Ketamine (a) is presented as a racemic mixture (b) is a glutamate receptor antagonist (c) directly causes sympathomimetic effects (d) is readily metabolised by hydroxylation to form nor-ketamine (e) increases uterine contractility Questions 41 The following local anaesthetic agents have a liver biotransformation (a) lidocaine (b) procaine (c) bupivacaine (d) amethocaine (e) ropivacaine 42 Cocaine (a) causes bronchoconstriction (b) causes vomiting (c) rarely causes allergic reactions (d) is excreted largely unchanged in the urine (e) competes with norepinephrine for reuptake pathways 43 Morphine is metabolised by the following mechanisms (a) glucuronide formation (b) N-dealkylation (c) acetylation (d) hydrolysis of an ester linkage (e) oxidative deamination 44 Tramadol (a) is a racemic mixture of two enantiomers (b) enhances noradrenaline neuronal uptake MCQs MCQs for the Primary FRCA Paper 2 40 Methohexitone (a) is 6 times more potent than thiopentone (b) causes excitatory movements (c) in aqueous solution has 6 parts 100 of sodium bicarbonate by weight (d) has a shorter elimination half-life than thiopentone (e) is most commonly used for electro-convulsive therapy.

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