Mechanisms of Atrial Arrhythmias: Insights from the by Michael A. Colman

By Michael A. Colman

This thesis describes the improvement of biophysically specified computing device types of the human atria and torso to check the underlying mechanisms of cardiac ailments, the most universal motives of morbidity and mortality. it is a cross-disciplinary undertaking, concerning basics of cardiac electrophysiology, physics of excitable media, utilized arithmetic and excessive functionality medical computing and visualisation. the writer makes use of desktop versions to supply insights into the underlying mechanisms of the genesis of atrial traumatic inflammation and develops novel concepts for the tracking of atrial tachycardia.

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Additional resources for Mechanisms of Atrial Arrhythmias: Insights from the Development of a Biophysically Detailed Model of the Human Atria

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After this time, it is stepped back down to the holding potential (Fig. 13a-i). This is then repeated for different test potentials, usually in increments of 10 mV, somewhere in the range -140 to 60 mV. The exact range and clamp time is dependent on the current being measured. Either the peak current during the test potential, the current at the end of the test potential or the tail current (the current just after the voltage is stepped back to the holding potential) is returned (illustrated in Fig.

Phase 4 of the AP is no longer stable and hence it has less meaning to denote it a ‘resting potential’. Instead, If and ICaT act to slowly depolarise the potential (Sect. 5). The gradient of the upstroke during phase 0 is significantly shallower due to a lower expression of INa. They have a distinct lack of a phase 1 notch or flattening during the phase 2 plateau. Instead, phase 3 directly follows phase 0. 4 The Sarcoplasmic Reticulum, the CICR Cycle and the Ca2+ Transient The sarcolemmal ion currents not only act to change the transmembrane potential but also the concentrations of the respective ions in the intracellular space.

2 Nernst Equilibrium Potential The Nernst equilibrium potential, also known as the reversal potential, and denoted Er, is the potential at which the electric force, due to the charge gradient, and the chemical force, due to the concentration gradient, across the cell membrane are of equal magnitude and in opposite directions [58]. Hence, at this potential the electrochemical force on an ion is zero. This means that there is no net flow of charge through a passive ion channel, and hence the current is also zero.

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