Microarray Gene Expression Data Analysis: A Beginner's Guide by Helen Causton, John Quackenbush, Alvis Brazma

By Helen Causton, John Quackenbush, Alvis Brazma

Mphasizing underlying innovations and rules, this concise advisor describes the layout of microarray experiments and the research of the knowledge they produce. meant for graduate scholars and bioinformatics researchers, the publication stresses the conceptual facets of research and retains mathematical complexities to a minimal.

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And Kung, C. (1987). A pressuresensitive ion channel in Esrliericlii~icoli. Pror. Null. Arud. Sci. U . S . A . 84, 2297-2301. , and Mischke. C. (1984). Ion channels in plasmalemma of wheat protoplasts. Science 226, 835-838. Naitoh. Y. (1974). Bioelectric basis of behavior in protozoa. Am. Z o o / . 14, 883-893. Oertel. , Shein, S. , and Kung, C. (1977). Separation of membrane currents using a Purumcriiim mutant. Nutwe (London) 268, 120-1 24. Ohmori, H. (1984). Mechanoelectrical transducer has discrete conductances in the chick vestibular hair cell.

1974). Wallace (1987) discusses the evidence that the preferred channel is the head-to-head dimer in Chapter 3 of this vofume. VI. ION CONDUCTION THROUGH THE PORE A. The Ion Fluxes Are Not Independent The simplest mechanism for ion conduction through a pore would have the permeant ions diffusing through the pore much as they do through the aqueous phases. In that case both anions and cations would be permeable, there would rarely be any ions in the pore simply because its volume is small. and the conductance would increase linearly with the ion ioncentration.

Finkelstein, A. (1974). Aqueous pores created in thin lipid membranes by the antibiotics nystatin, amphotericin B and gramicidin A: implications for pores in plasma membranes. I n “Drugs and Transport Processes” (B. A. ), pp. 241-250. Macmillan. London. Finkelstein, A.. and Andersen, 0. S. (1981). The gramicidin A channel: A review of its 2. GRAMICIDIN: CONCLUSIONS BASED ON DATA 31 permeability characteristics with special reference to the single file aspect of transport. J . Memhr. B i d . 59.

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