Mitochondrial DNA Mutations in Aging, Disease and Cancer by Dongchon Kang, Koichiro Takeshige (auth.), Keshav K. Singh

By Dongchon Kang, Koichiro Takeshige (auth.), Keshav K. Singh Ph.D. (eds.)

Many human genetic ailments linked to blood, mind, colon, ear, eye, middle, kidney, liver, muscle, and pancreas are brought on by mutations in mitochondrial DNA. Mutations in DNA may end up in defects of the electron delivery complexes, intermediates of the tricarboxylic acid cycle and substrate shipping. The scientific manifestation of those ailments frequently contains muscle and the frightened method. Mitochondrial DNA mutations have now been linked to getting older in addition to age-related degenerative illnesses corresponding to Parkinson's, Alzheimer's, and Huntington's ailments. adjustments in constitution, functionality, and a few mitochondria play an enormous function in carcinogenesis. moreover, the position of mitochondria within the execution of programmed telephone loss of life or apoptosis has been famous recently.

Show description

Read Online or Download Mitochondrial DNA Mutations in Aging, Disease and Cancer PDF

Similar cancer books

Therapeutic Resistance to Anti-hormonal Drugs in Breast Cancer: New Molecular Aspects and their Potential as Targets

One of many major motives of failure within the therapy of breast melanoma is the intrinsic presence of, or improvement of, drug resistance by way of the melanoma cells. fresh stories at the mechanisms of melanoma drug resistance have yielded vital info highlighting either how tumour cells may perhaps get away those healing constraints and that drug resistance may possibly additional impinge on tumour telephone features which can eventually advertise an hostile phone phenotype.

An Omics Perspective on Cancer Research

Omics is an rising and intriguing sector within the box of technology and drugs. a number of promising advancements were elucidated utilizing omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinformatics) in melanoma learn. the improvement of high-throughput applied sciences that let the answer of decoding melanoma from larger dimensionality will supply an information base which alterations the face of melanoma figuring out and therapeutics.

Cancer Active Immunotherapy: Immunoprophylaxis and Immunorestoration

I want to thank all my co-workers who've collaborated with me, from 1963 in the past, in organic and medical examine within the box of melanoma lively immunotherapy, of its immuno­ prevention and immunorestoration. they'll usually be quoted during this e-book. i'm fairly thankful to those that have helped me to jot down it through reviewing a few chapters: D.

Extra info for Mitochondrial DNA Mutations in Aging, Disease and Cancer

Example text

Biochim Biophys Acta 1991; 1071:291-312. 36. Lea PJ, Hollenberg MJ. Mitochondrial structure revealed by high resolution scanning electron microscopy. Am J Anat. 1989; 184: 245-257. 37. Winslow JL, Hollenberg MJ, Lea PJ. Resolution limit of serial sections for 3D reconstruction of tubular cristae in rat liver mitochondria. J Electron Microsc Tech 1991; 18:241-248. 38. Mannella CA, Marko M, Penczek P, Barnard D, Frank J. The internal compartmentation of rat-liver mitochondria: tomographie study using the high-voltage transmission electron mieroscope.

Electron-transport linked ultrastructural transformations in mitochondria. J Cell Biol 1968; 37:345-354. Mitochondrial DNA Mutations in Aging, Disease and Cancer 35. Brdiezka D. Contact sites between mitochondrial envelope membranes. Structure and function in energy- and protein-transfer. Biochim Biophys Acta 1991; 1071:291-312. 36. Lea PJ, Hollenberg MJ. Mitochondrial structure revealed by high resolution scanning electron microscopy. Am J Anat. 1989; 184: 245-257. 37. Winslow JL, Hollenberg MJ, Lea PJ.

107 These can interact with a wide variety of unfolded proteins and assist the folding process through cydes of binding and release. Some monomeric mitochondrial proteins can fold without the assistance of Hsp60, while the folding of others is assisted by mitochondrial HSP70 or by a cydosporin-sensitive proline rotarnase. In Neurospora, mitochondrial HSP70 also helps fold some mitochondrial encoded proteins, and 32 Mitochondrial DNA Mutations in Aging, Disease and Cancer this is probably true in other organisms.

Download PDF sample

Rated 4.78 of 5 – based on 50 votes