Peptide Hormones in Lung Cancer by J. M. Polak, S. R. Bloom (auth.), Professor Dr. Klaus

By J. M. Polak, S. R. Bloom (auth.), Professor Dr. Klaus Havemann, George Sorenson MD, Priv. Doz. Dr. Claus Gropp (eds.)

The prevalence of lung melanoma has reached epidemic proportions in the course of the civilized international. One indication of the size of this challenge is that during the U.S. lung melanoma has turn into the best reason behind melanoma loss of life in ladies in addition to males. In 1912 there has been a "nearly entire consensus of opinion that basic malignant neoplasms of the lung (were one) of the rarest types of disease," in keeping with Adler. by way of 1937, although, it had turn into transparent that the occurrence of lung melanoma was once expanding considerably; this elevate has been innovative ever considering that. it really is now renowned that a few lung cancers supply upward thrust to quite a few hormones which, now and then, produce medical manifestations. The organization of hormone creation with a "nonendocrine" tumor increases many questions, the solutions to which could shed a few gentle at the etiology of this familiar type of melanoma. This interesting prob­ lem has inspired a wide selection of stories in either the medical and the elemental sciences. some of the more moderen reports during this box have been mentioned on the overseas Symposium on Peptide Hor­ mones and Lung melanoma held in Marburg, West Germany, on June 18-20, 1984. This quantity comprises the papers that have been pre­ sented in this occasion.

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For example, a patient Peptide Hormones and Their Possible Functions in the Normal and Abnormal Lung 25 with epidermoid cancer of the lung is usually a heavy smoker with chronic obstructive pulmonary disease and/or smoking-related bronchitis. Patients with these last complications often have increased blood levels of calcitonin, ACTH, and P-lipotropin, which are not necessarily produced by the tumor (Becker et al. 1984). Also, interpretations of studies which involve immunoperoxidase staining of a tumor or radioimmunoassay of extracted tumor tissue must take into consideration the fact that pulmonary cancers often are not homogeneous; they may include different cell types (Gazdar 1984) and also may include areas of non-neoplastic adjacent pulmonary parenchyma which contain areas of hyperplastic pulmonary endocrine cells (Becker et al.

Lancet I: 1270 Hamasaki Y, Saga T, Mojarad M, Said SI (1982) VIP reduces or abolishes the contractile effects of leukotriene D4 on guinea pig trachea, pulmonary artery and lung parenchyma. Clin Res 30: 879A Hara N, Geumei A, Chijimatsu Y, Said SI (1975) Vasoactive intestinal peptide aerosol protects against histamine and prostaglandin F 2a-induced bronchoconstriction. Clin Res 23: 347A Heymann MA, Rudolph AM, Nies AS, Melman KL (1969) Bradykinin production associated with oxygenation of the fetal lamb.

1979), release of histamine from pulmonary mast cells (Church et al. 1982), pulmonary vasoconstriction (Voelkel et al. 1980), and the synthesis and pulmonary effects of arachidonic acid metabolites (Wong and Cheung 1979; Weichman et al. 1983). In this regard, calcitonin influences transcellular and intracellular movements of calcium (Yamaguchi et al. 1975; Parkinson and Radde 1969), and the intrapulmonary role of this hormone merits further investigation. Neurotensin Neurotensin, which has been found in normal chicken lung (Carraway et al.

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