Phosphoinositides and Disease by Tania Maffucci (auth.), MARCO FALASCA (eds.)

By Tania Maffucci (auth.), MARCO FALASCA (eds.)

Phosphoinositides (PIs) are minor elements of mobile membranes that play serious regulatory roles in numerous intracellular services. This ebook describes the most enzymes regulating the turnover of every of the seven PIs in mammalian cells, a few of their intracellular capabilities and a few facts in their involvement in human ailments. as a result complicated inter-relation among the targeted PIs and the plethora of capabilities that they could keep watch over inside of a telephone, this e-book isn't really intended to be a accomplished insurance of all features of PIs signalling yet relatively an summary at the present country of the sector and the place it will probably cross from the following. Phosphoinositide and inositol phosphates engage with and modulate the recruitment and activation of key regulatory proteins and in doing so keep watch over different capabilities together with telephone development and proliferation, apoptosis, cytoskeletal dynamics, insulin motion, vesicle trafficking and nuclear functionality. at the beginning, inositide signaling used to be restricted to the PLC pathway; although, it truly is now transparent that each one the seven phosphoinositides and greater than 30 diversified inositol phosphates most likely have particular signaling capabilities. additionally there's a transforming into checklist of proteins which are regulated via inositol signaling. This has raised the query as to how inositol signaling can keep watch over various tactics and but retain signaling specificity. Controlling the degrees of inositol signaling molecules and their subcellular compartmentalisation might be serious. This assembly will collect scientists from diverse backgrounds to debate how realizing inositol signaling can be utilized to focus on advanced human illnesses that appear themselves whilst inositol signaling is deregulated.

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J Biol Chem 277:47276–47284 Sbrissa D, Ikonomov OC, Strakova J et al (2004) Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation. Endocrinology 145:4853–4865 Shaw RJ, Cantley LC (2006) Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441:424–430 Shayesteh L, Lu Y, Kuo WL et al (1999) PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 21:99–102 She QB, Solit D, Basso A et al (2003) Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3’-kinase/Akt pathway signaling.

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