Postnatal Development of the Human Hippocampal Formation by Ricardo Insausti

By Ricardo Insausti

The postnatal improvement of the human hippocampal formation (HF) is topic of accelerating curiosity because of its implication in very important pathologies that abate the conventional improvement of youngsters. during this paintings, the authors current a glimpse of the most occasions that represent very important milestones within the improvement and shaping of a few of an important mental services equivalent to autobiographical reminiscence. even though they tested a few instances within the final trimester of gestation, their description begins at delivery, round forty gestational weeks. Serial sections with thionin for Nissl research printed that every one fields of the HF have been current and identifiable at beginning. even though, the relative progress of the cortical mantle was once a lot better relative to the HF. the most structural alterations came about in the course of the first postnatal yr, specifically within the dentate gyrus and within the entorhinal cortex. At next a long time, a development in dimension used to be famous in all elements of the HF. This progress was once extra obtrusive on the physique and tail of the hippocampus, as evidenced by way of measurements of the neuroanatomical sequence. moreover, the authors tested every now and then the MRI visual appeal of the HF at diversified postnatal a long time received through autopsy imaging. MRI neuroanatomical sequence supplied anatomically pointed out landmarks precious for the MRI identity of other elements of the HF in the course of postnatal development.

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Thus, CA2 is limited to a cell layer that is closer to the stratum radiatum that presents a higher cell packing density (Fig. 12b). In contrast, the border between CA2 and CA1 is easily noticeable because of both the larger CA2 neurons and the stronger staining density they present compared to CA1 pyramidal neurons. At birth, there is a band of more closely packed neurons at the border with the stratum radiatum (Fig. 12b) that is also present at later ages. While the definition of the border between CA3 and CA2 hardly improves, the limit with CA1 becomes progressively better defined (Fig.

7). In contrast to CA1, the subiculum lacks the orderly disposition of layers seen in CA fields of the ◂ Fig. 6 Series of photomicrographs of field CA1 in the newborn (a), one year old (b), five year old (c) and 14 year old (d). As in the other ammonic fields, the strata are well defined at the time of birth (a), but they become more clearly defined with age. However, the pyramidal cell layers in CA1 and the subiculum (S) look very similar, especially up to one year of age. At five years old (c) and 14 years (d) old, the neuronal profiles in the pyramidal cell layer are better defined, so the separation between CA1 and the subiculum is somewhat more evident.

3c, d). A gross examination of the medial temporal lobe indicates that it is mainly the body and tail of the hippocampus that present the greatest increases in length during the first postnatal year. Moreover, an overall microscopic examination reveals that the rostrocaudal sequence of the different components of the MTL (HF and PHR) maintain their relative positions along the rostrocaudal axis during postnatal development. Although we will consider this in more depth later, the set of low-power photomicrographs shown in Figs.

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