Process Simulation and Data Modeling in Solid Oral Drug by Marianthi G. Ierapetritou, Rohit Ramachandran

By Marianthi G. Ierapetritou, Rohit Ramachandran

This thorough quantity goals to supply pharmaceutical engineers with an creation to the present cutting-edge in modeling and simulation of pharmaceutical procedures and to summarize a couple of sensible functions of appropriate methodologies in drug product improvement. Chapters contain explorations of simulation and modeling methodologies, facts assortment and research, improvement of novel sensing strategies, improvement and integration of person unit types, optimization techniques for data-based types, layout house review suggestions, informatics-based methodologies, and rising subject matters in pharmaceutical procedure improvement. As part of the Methods in Pharmacology and Toxicology sequence, the chapters comprise the type of element and implementation suggestion that may make the transition into the laboratory as tender as possible.

Authoritative and leading edge, Process Simulation and information Modeling in sturdy Oral Drug improvement and Manufacture seeks to advertise examine into approach platforms methodologies and their program in pharmaceutical product and procedure improvement, with a purpose to unquestionably turn into an more and more vital quarter within the future.

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However, researchers in the field of amorphous API/polymer solid solutions have risen to the challenge and developed methods capable of determining the thermodynamic solubility of API’s in these polymer blends. Typically, Differential Scanning Calorimetry (DSC) is used, sometimes in combination with other supporting techniques such as Powder X-Ray Diffraction (PXRD), Hot Stage Microscopy (HSM), and Infrared spectroscopy (IR) [71, 79, 88, 91–95]. Use of DSC in combination with improved sample preparation via cryomilling [71, 91] and in some cases annealing the sample [92] has been demonstrated to produce results that are sufficiently accurate to be used in design of the amorphous API/polymer solid solution formulations [71].

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