Seminars in RT: Current Controversies in Rectal Cancer by J. E. Tepper, MD

By J. E. Tepper, MD

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9,10 In this phase III study, 1,350 patients with clinically resectable rectal cancer were randomized to short-course preoperative radiation therapy (25 Gy in 5 fractions) and TME versus TME followed by selective postoperative chemoradiation (45 Gy in 25 fractions with 5-FU) for patients with tumor invasion of the circumferential resection margin. In addition, patients with stage III disease received postoperative chemotherapy. 6%, respectively). 5%, respectively). Overall survival did not differ between the groups.

J Clin Oncol 28:256-263, 2010 16. Hu-Lieskovan S, Yang D, Grimminger PP, et al: Use of EGF aϩ61G and TS-5’UTR 2R/3R polymorphisms to predict complete pathologic response in locally advanced rectal cancer patients undergoing preoperative cetuximab-based chemoradiation followed by surgery. J Clin Oncol 28:3641, 2010 (abstr) 17. Tanaka M, Bedrosian I, Chang GJ, et al: Correlation of single nucleotide polymorphisms (SNPs) of hypoxia-related genes with pathologic complete response (pCR) following neoadjuvant chemoradiation (chemoXRT) for locally advanced rectal cancer.

Gunderson LL, Jessup JM, Sargent DJ, et al: Revised tumor and node categorization for rectal cancer based on surveillance, epidemiology, and end results and rectal pooled analysis outcomes. J Clin Oncol 28:256-263, 2010 16. Hu-Lieskovan S, Yang D, Grimminger PP, et al: Use of EGF aϩ61G and TS-5’UTR 2R/3R polymorphisms to predict complete pathologic response in locally advanced rectal cancer patients undergoing preoperative cetuximab-based chemoradiation followed by surgery. J Clin Oncol 28:3641, 2010 (abstr) 17.

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