By Simon J. Morley (auth.), Professor Dr. Robert E. Rhoads (eds.)
This quantity provides the reaction of the eukaryotic translational gear to mobile pressure and apoptosis, together with kinases activated via either the ERK and stress-activated pathways. It additional explores brokers that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written via best specialists within the box offer either new facts and finished literature studies. either the rules of initiation and elongation are mentioned, and the mechanisms of apoptosis are on the topic of alterations within the protein synthesis machinery.
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Additional resources for Signaling Pathways for Translation: Stress, Calcium, and Rapamycin
Data). Cleavage of eIF4B and eIF3p35 occurred with delayed kinetics relative to those seen for eIF4GI, and was also observed in response to serum deprivation and treatment of cells with anti-Fas antiserum or etoposide. The cleavage of eIF4GI, the transient increase in the phosphorylation of eIF2a, and the increased association of 4E-BPI with eIF4E was also observed with other inducers of apoptosis, such as etoposide or staurosporine (S. Modey, unpubl. data). As with eIF4GI, caspase-3 activity was both necessary and sufficient for eIF3p35 and eIF4B cleavage in vitro; however eIF4B was also cleaved during apoptosis in MCF-7 cells lacking caspase-3 (LW.
Pestova TV, Borukhov SI, Hellen CUT (1998) Eukaryotic ribosomes require initiation factors 1 and 1 A to locate initiation co dons. Nature 394:854-859 Pestova TV, Lomakin IB, Choi SK, Dever TE, Hellen CUT (2000) The joining of ribosomal subunits in eukaryotes requires eIF5B. Nature 403:332-335 Peter ME, Heufelder AE, Hengartner MO (1997) Advances in apoptosis research. Proc Natl Acad Sci USA 94:12736-12737 Piron M, Vende P, Cohen J, Poncet D (1998) Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F.
Proc Natl Acad Sci USA 96:13118-13123 Joshi B, Cai A-L, Keiper BD, Minich WB, Mendez R, Beach CM, Stepinski J, Stolarski R, Darzynkiewicz E, Rhoads RE (1995) Phosphorylation of eukaryotic protein synthesis initiation factor 4E at Ser-209. J Biol Chem 270:14597-14603 Joshi-Barve S, Rychlik W, Rhoads RE (1990) Alteration of the major phosphorylation site of eukaryotic pro tein synthesis initiation factor 4E prevents its association with the 48 S initiation complex. J Biol Chem 265:2979-2983 Kerekatte V, Keiper BD, Badorff C, Cai AL, Knowlton KU, Rhoads RE (1999) Cleavage of poly(A)binding protein by Coxsackie virus 2 A protease in vitro and in vivo: Another mechanism for host protein synthesis shutoff.