Structure and Function of the Neural Cell Adhesion Molecule by Vladislav Soroka, Christina Kasper, Flemming M. Poulsen

By Vladislav Soroka, Christina Kasper, Flemming M. Poulsen (auth.), Vladimir Berezin (eds.)

Adhesive interactions are vital for phone trafficking, differentiation, functionality and tissue formation. within the fearful process, many telephone adhesion molecules (CAMs) are concerned with migration of neuroblasts, outgrowth and fasciculation of neuronal strategies, formation of synapses and rearrangements of synaptic contacts linked to plasticity together with studying and reminiscence. greater than 80 CAMs have been stumbled on to be localized at synaptic websites, the place they in a regulated demeanour bridge pre- and postsynaptic specializations thereby modulating synaptic functionality. Structure and serve as of the Neural phone Adhesion Molecule NCAM describes fresh advancements relating structural, sensible and attainable healing features of 1 specific CAM, the neural mobilephone adhesion molecule (NCAM). NCAM is among the first pointed out and so much studied CAMs, and this ebook is the 1st try and jointly summarize our present wisdom of this significant mobilephone adhesion molecule.

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Atkins AR, Osborne MJ, Lashuel HA et al (1999) Association between the first two immunoglobulin-like domains of the neural cell adhesion molecule N-CAM. FEBS Lett 451:162–168 30. Soroka V, Kiryushko D, Novitskaya V et al (2002) Induction of neuronal differentiation by a peptide corresponding to the homophilic binding site of the second Ig module of NCAM. J Biol Chem 227:24676–24683 31. Lahrtz F, Horstkorte R, Cremer H et al (1997) VASE-encoded peptide modifies NCAM- and L1-mediated neurite outgrowth.

Proc Natl Acad Sci USA 104:15358–15363 58. Johnson CP, Fragneto G, Konovalov O et al (2005) Structural studies of the neural-celladhesion molecule by X-ray and neutron reflectivity. Biochemistry 44:546–554 59. Hall AK, Rutishauser U (1987) Visualization of neural cell adhesion molecule by electron microscopy. J Cell Biol 104:1579–1586 60. Becker JW, Erickson HP, Hoffman S et al (1989) Topology of cell adhesion molecules. Proc Natl Acad Sci USA 86:1088–1092 61. Hunte C, Michel H (2002) Crystallisation of membrane proteins mediated by antibody fragments.

J Neurochem 95:570–583 37. Jacobsen J, Kiselyov V, Bock E et al (2008) A peptide motif from the second fibronectin module of the neural cell adhesion molecule, NCAM, NLIKQDDGGSPIRHY, is a binding site for the FGF receptor. Neurochem Res 32(12):2532–2539 38. Dickson G, Gower HJ, Barton CH et al (1987) Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain. Cell 50:1119–1130 39. Rao Y, Wu X-F, Gariepy J et al (1992) Identification of a peptide sequence involved in homophilic binding in the neural cell adhesion molecule NCAM.

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