The aminoacyl-tRNA synthetases by Michael Ibba

By Michael Ibba

The realm of aminoacyl-tRNA synthetases / Paul Schimmel and Dieter Soll -- Arginyl-tRNA synthetases / Gilbert Eriani and Jean Cavarelli -- Cysteinyl-tRNA synthetases / Ya-Ming Hou and John J. Perona -- Isoleucyl-tRNA synthetases / Brian E. Nordin and Paul Schimmel -- Leucyl-tRNA synthetases / Tommie L. Lincecum, Jr. and Susan A. Martinis -- Methionyl-tRNA synthetases / Sylvain Blanquet ... [et al.] -- Valyl-tRNA synthetases / Osamu Nureki and Shigeyuki Yokoyama -- category I lysyl-tRNA synthetases / Alexandre Ambrogelly ... [et al.] -- Glutaminyl-tRNA synthetases / John J. Perona -- Glutamyl-tRNA synthetases / Daniel Y. Dubois, Jacques Lapointe, and Shun-ichi Sekine -- Trytophanyl-tRNA synthetases / Charles W. Carter -- Tyrosyl-tRNA synthetases / Hugues Bedouelle -- Glycyl-tRNA synthetases / Kiyotaka Shiba -- Histidyl-tRNA synthetases / Chris Francklyn and John Arnez -- Prolyl-tRNA synthetases / Karin Musier-Forsyth, Brian Burke, and Stephen Cusack -- Threonyl-tRNA synthetases / Anne-Catherine Dock-Bregeon, Pascale Romby, and Mathias Springer -- Seryl-tRNA synthetases / Ivana Weygand-Durasevic and Stephen Cusack -- Asparaginyl-tRNA Synthetases / Daniel Kern, Herve Roy, and Hubert Dominique Becker --, Aspartyl-tRNA synthetases / Richard Giege and Bernard Rees -- type II lysyl-tRNA synthetases / Sylvain Blanquet, Pierre Plateau, and Silvia Onesti -- Alanyl-tRNA synthetases / Lluis Ribas de Pouplana, Karin Musier-Forsyth, and Paul Schimmel -- Phenylalanyl-tRNA synthetases / Mark Safro, Nina Moor, and Olga Lavrik -- tRNA aminoacylation / William H. McClain -- Mitochondrial aminoacyl-tRNA synthetases / Marie Sissler ... [et al.] -- tRNA synthetase-like proteins / Christopher Francklyn -- Multi-aminoacyl-tRNA synthetase complexes / Marc Mirande -- rules of aminoacyl-tRNA synthetase gene expression in micro organism / Tina M. Henkin -- move RNA-dependent amidotransferases / Liang Feng ... [et al.] -- Selenocysteine / August Bock ... [et al.] -- Catalysis of the tRNA aminoacylation response / Eric A. First -- Proteins with a number of unnatural amino acids / Caroline Kohrer and Uttam L. Raj Bhandary -- Ribozyme-catalyzed tRNA aminoacylation / Hiroaki Suga, Hirohide Saito, and David R.W. Hodgson -- Protein tagging and ribosome rescue in micro organism calls for the popularity of transfer-messenger RNA via an aminoacyl-tRNA synthetase / Brice Felden, Reynald Gillet, and Laurent Metzinger -- Accuracy of aminoacyl-tRNA synthetases / Hieronim Jakubowski -- Aminoacyl-tRNA synthetases and sickness / Michael Kron and Michael Hartlein -- Aminoacyl-tRNA synthetases as anti-infective drug pursuits / John Finn and Jianshi Tao

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12. Newberry KJ, Hou YM, Perona JJ et al. Structural origins of amino acid selection without editing by cysteinyl- tRNA synthetase. EMBO J 2002; 21:2778-2787. 13. Zhang CM, Christian T, Newberry KJ et al. Zinc mediated amino acid discrimination in cysteinyl-tRNA synthetase. J Mol Biol 2002; 327:911-917. 14. Sugiura I, Nureki O, Ugaji-Yoshikawa Y et al. 0 A crystal structure of Thermus thermophilus methionyl-tRNA synthetase reveals two RNA-binding modules. Structure Fold Des 2000; 8:197-208. 15.

Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove. Science 1991; 253:784-6. 41. Musier-Forsyth K, Scaringe S, Usman N et al. Enzymatic aminoacylation of single-stranded RNA with an RNA cofactor. Proc Natl Acad Sci USA 1991; 88:209-13. 42. Musier-Forsyth K, Schimmel P. Functional contacts of a transfer RNA synthetase with 2'-hydroxyl groups in the RNA minor groove. Nature 1992; 357:513-5. 43. Musier-Forsyth K, Shi JP, Henderson B et al. Base-Analog-Induced Aminoacylation of an RNA Helix by a tRNA Synthetase.

Coli CysRS can cross-aminoacylate a wide-range of prokaryotic tRNACys, it cannot aminoacylate eukaryotic tRNACys having the D3V5 structure. For example, E. coli CysRS and the closely related H. influenzae enzyme can efficiently aminoacylate each other’s tRNA and tRNACys of several eubacterial species (H. pylori, B. subtilis and M. 30 Thus, while the prokaryotic enzymes critically discriminate details of the tertiary core, the eukaryotic enzymes are less selective. Indeed, for E. 30 Chemical probing analysis of the reengineered core of eukaryotic tRNACys suggests a structural similarity to the core of E.

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