The Centrosome: Cell and Molecular Mechanisms of Functions by Tomer Avidor-Reiss, Jayachandran Gopalakrishnan, Stephanie

By Tomer Avidor-Reiss, Jayachandran Gopalakrishnan, Stephanie Blachon, Andrey Polyanovsky (auth.), Heide Schatten (eds.)

The Centrosome: cellphone and Molecular Mechanisms of features and Dysfunctions in Disease comprises chapters on vintage and smooth points of centrosome study to hide subject matters of present curiosity that experience no longer been lined intensive in such a lot books out there to this point. It extends on prior issues and contains new intriguing facets of centrosome examine enthusiastic about fundamental cilia and their dysfunctions which are implicated in several ailments. each one bankruptcy might be written by means of specialists of their fields who will give a contribution their designated services in particular examine fields and contain telephone and molecular info which are very important for the explicit subtopics. The ebook might be finished, concise and should comprise reports of key themes within the box. leading edge new info can be balanced with historical past info that would be without difficulty comprehensible for the newcomer and the skilled centrosome researcher alike.

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Extra resources for The Centrosome: Cell and Molecular Mechanisms of Functions and Dysfunctions in Disease

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4 Phenotypic Characterization of Centrosomal Mutants The spermatid flagellum is formed in a unique way from that of sensory cilia (Avidor-Reiss et al. 2004; Han et al. 2003). Sensory cilia are formed within a distinct compartment separated from the rest of the cell by a transition zone that is thought to function as the ciliary gate (Betleja and Cole 2010; Craige et al. 2010; Omran 2010; Williams et al. 2011). As a result, sensory cilium formation requires a complex machinery known as the intra-flagellar transport (IFT) (Rosenbaum 2002; Scholey and Anderson 2006).

2004; Fritz-Laylin and Cande 2010; Gonczy et al. 2000; Keller et al. 2005; Kilburn et al. 2007; Li et al. 2004; Mahoney et al. 2006). 1). Some of the important discoveries regarding these proteins that were made using flies are summarized below. 6 Identification of Centrosomal Proteins and Mutants in Drosophila melanogaster Identification of centrosomal components that play a specific role in centrosome have been hampered by initial difficulties in obtaining sufficient quantities of material for biochemical isolation and a lack of clear phenotypes expected from mutation of essential centrosomal proteins.

Omran H (2010) NPHP proteins: gatekeepers of the ciliary compartment. J Cell Biol 190:715–717 Pearson CG, Osborn DP, Giddings TH Jr, Beales PL, Winey M (2009) Basal body stability and ciliogenesis requires the conserved component Poc1. J Cell Biol 187:905–920 Peel N, Stevens NR, Basto R, Raff JW (2007) Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation. Curr Biol 17:834–843 Pelletier L, Ozlu N, Hannak E, Cowan C, Habermann B, Ruer M, Muller-Reichert T, Hyman AA (2004) The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication.

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