The Metastatic Spread of Cancer: Reflections upon its by G. V. Sherbet (auth.)

By G. V. Sherbet (auth.)

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1983). Murine EGF has been reported to show some homology (21% of amino acid residues) with the inactive A chain of t-PA and u-PA (Bachman and Kruithof, 1984). Although the homologous sections do not occur as defined domains, these common sequences could conceivably stimulate tumour growth. All this should highlight the importance of the hormonal milieu in the assessment of P A, whether in the primary or in the metastatic tumour, and its relevance to the process of formation of secondary tumours.

Russel and Rubinstein (1977) appear to be making such a distinction when they refer to the former as metastasis and the latter as 'remote' metastasis. Kernohan and Sayre (1958) stated unequivocally that, 'if the term malignant is to be restricted to those tumours which metastasise, then most, if not all, tumours of the central nervous system should be excluded'. Implicit in this statement is the acceptance that CNS tumours do not show true metastasis. CNS tumours will cause death merely by raising intracranial pressure, unless the tumours are excised and residual tumour tissue is destroyed.

The invasive behaviour of brain tumours can be extrapolated with validity only using autologous systems such as embryonic brain tissues in organ culture. The most valuable approach would be to use labelled monoclonal antibodies for localising the tumour which could define more precisely the degree of infiltration and invasiveness of a given glioma. Adhesive Glycoproteins of the Cell Membrane The importance of the enzymatic processes for the degradation of the intercellular matrix and release of tumour cells or clumps of tumour cells from the primary lesion and the adhesion of released tumour cells to the The Metastatic Cascade 37 basement membrane of the capillaries or to the endothelium of the lymphatics is emphasised sufficiently by the foregoing discussion.

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